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HIF1A — IKBKB

Text-mined interactions from Literome

Rius et al., Nature 2008 (Anoxia...) : IKK-beta deficiency results in defective induction of HIF-1alpha target genes including vascular endothelial growth factor ... IKK-beta is also essential for HIF-1alpha accumulation in macrophages experiencing a bacterial infection
Kuo et al., Biochem Biophys Res Commun 2009 (Breast Neoplasms) : TNFalpha induces HIF-1alpha expression through activation of IKKbeta ... Increased HIF-1alpha expression was found in IKKbeta stable clones and transient transfectants, and depletion of IKKbeta consistently reduced the amount of HIF-1alpha protein ... Our findings indicate that TNFalpha induced HIF-1alpha accumulation is IKKbeta dependent , and may enable further understanding of the HIF-1alpha regulation by inflammatory signals