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ITGA6 — RAC1
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Mohri et al., Exp Cell Res 1999
(Colonic Neoplasms) :
In light of this evidence, we propose that the regulation of
integrin alpha6beta4 expression
induced by
Rac1 and Cdc42 may play an important role in cell adhesion and tumorigenesis of colon carcinoma cells
Friedland et al., J Cell Sci 2007
:
We report that elevated (
alpha6)beta4 integrin dependent
Rac-Pak1 signaling supports resistance to apoptosis in mammary acini by permitting stress dependent activation of the p65 subunit of NF-kappaB through Pak1 ... Thus, mammary tissues can resist apoptotic stimuli by activating NF-kappaB through
alpha6beta4 integrin dependent
Rac-Pak1 signaling ... Our data emphasize the importance of the extracellular matrix stroma in tissue survival and suggest that
alpha6beta4 integrin dependent
Rac stimulation of Pak1 could be an important mechanism mediating apoptosis-resistance in some breast tumors
Cruz-Monserrate et al., Neoplasia (New York, N.Y.) 2008
(Adenocarcinoma...) :
Integrin alpha 6 beta 4 promotes migration, invasion through Tiam1 upregulation, and subsequent
Rac activation ... Furthermore, the activity of the small GTPase
Rac1 was
stimulated by
alpha 6 beta 4 integrin expression and was necessary for HGF stimulated chemotaxis
Chai et al., Int J Mol Med 2010
:
Upon activation,
Rac1 increased surface
alpha6/beta1 integrin levels and promoted colony forming efficiency of ESCs