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IL1B — SPP1
Text-mined interactions from Literome
Himeno et al., J Bone Miner Res 2002
(Ossification, Heterotopic) :
In primary culture of Cbfa1-/- chondrocytes, transforming growth factor (TGF) beta1, platelet derived growth factor ( PDGF ),
interleukin (IL)-1beta , and thyroid hormone ( T3 )
induced osteopontin and MMP-13 expression
Xie et al., J Cell Physiol 2004
:
ERK1/2 and JNKs, but not p38 kinase, are involved in reactive oxygen species mediated
induction of
osteopontin gene expression by angiotensin II and
interleukin-1beta in adult rat cardiac fibroblasts
Serlin et al., J Cell Biochem 2006
:
Interleukin-1beta induces
osteopontin expression in pulmonary fibroblasts ... Our results demonstrate a potent and dramatic increase in
osteopontin expression
induced by
interleukin-1beta (IL-1beta) , whereas tumor necrosis factor-alpha, transforming growth factor-beta, and angiotensin II had minimal effect ... Stimulation with
IL-1beta resulted in the secretion of soluble
osteopontin protein
Lu et al., Allergy 2009
(Nasal Polyps...) :
On the contrary,
OPN induced IFN-gamma, IL-4, IL-5, IL-13,
IL-1beta , and TNF-alpha production in sinonasal mucosa
Lacey et al., Osteoarthritis Cartilage 2009
:
However, only TNFalpha inhibited osteonectin and
osteopontin mRNA expression and only
IL-1beta reduced cell proliferation
Singh et al., J Biol Chem 1995
:
In vitro,
interleukin-1 beta and interferon-gamma
increased osteopontin mRNA levels in CMEC as well as NOS2 expression in both CMEC and cardiac myocytes
Lee et al., J Korean Med Sci 1998
:
To investigate whether MCP-1, CINC, RANTES,
osteopontin and ICAM-1 mRNA could be
induced in cultured rat mesangial cells by
interleukin-1beta(IL-1beta) , tumor necrosis factor-alpha (TNF-alpha) and lipopolysaccharide (LPS), and whether MCP-1 and CINC gene expression could be modulated by dexamethasone, Northern blot assays were performed ... On the other hand,
IL-1beta , TNF-alpha and LPS
had little effect on
osteopontin gene expression but fetal calf serum could increase osteopontin mRNA