Gene interactions and pathways from curated databases and text-mining

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IL1B — SPP1

Text-mined interactions from Literome

Himeno et al., J Bone Miner Res 2002 (Ossification, Heterotopic) : In primary culture of Cbfa1-/- chondrocytes, transforming growth factor (TGF) beta1, platelet derived growth factor ( PDGF ), interleukin (IL)-1beta , and thyroid hormone ( T3 ) induced osteopontin and MMP-13 expression
Xie et al., J Cell Physiol 2004 : ERK1/2 and JNKs, but not p38 kinase, are involved in reactive oxygen species mediated induction of osteopontin gene expression by angiotensin II and interleukin-1beta in adult rat cardiac fibroblasts
Serlin et al., J Cell Biochem 2006 : Interleukin-1beta induces osteopontin expression in pulmonary fibroblasts ... Our results demonstrate a potent and dramatic increase in osteopontin expression induced by interleukin-1beta (IL-1beta) , whereas tumor necrosis factor-alpha, transforming growth factor-beta, and angiotensin II had minimal effect ... Stimulation with IL-1beta resulted in the secretion of soluble osteopontin protein
Lu et al., Allergy 2009 (Nasal Polyps...) : On the contrary, OPN induced IFN-gamma, IL-4, IL-5, IL-13, IL-1beta , and TNF-alpha production in sinonasal mucosa
Lacey et al., Osteoarthritis Cartilage 2009 : However, only TNFalpha inhibited osteonectin and osteopontin mRNA expression and only IL-1beta reduced cell proliferation
Singh et al., J Biol Chem 1995 : In vitro, interleukin-1 beta and interferon-gamma increased osteopontin mRNA levels in CMEC as well as NOS2 expression in both CMEC and cardiac myocytes
Lee et al., J Korean Med Sci 1998 : To investigate whether MCP-1, CINC, RANTES, osteopontin and ICAM-1 mRNA could be induced in cultured rat mesangial cells by interleukin-1beta(IL-1beta) , tumor necrosis factor-alpha (TNF-alpha) and lipopolysaccharide (LPS), and whether MCP-1 and CINC gene expression could be modulated by dexamethasone, Northern blot assays were performed ... On the other hand, IL-1beta , TNF-alpha and LPS had little effect on osteopontin gene expression but fetal calf serum could increase osteopontin mRNA