◀ Back to IL1B
IL1B — PRKAG2
Text-mined interactions from Literome
Giri et al., J Neurosci 2004
(Inflammation) :
A pharmacological activator of
AMPK , 5-amino-4-imidazole carboxamide riboside ( AICAR )
inhibited lipopolysaccharide (LPS) induced expression of proinflammatory cytokines ( tumor necrosis factor alpha,
interleukin-1beta , and interleukin-6 ) and inducible nitric oxide synthase in primary rat astrocytes, microglia, and peritoneal macrophages
Ropelle et al., Endocrinology 2007
(Anorexia...) :
In parallel, the pharmacological activation of hypothalamic
AMPK in TB animals markedly
reduced the hypothalamic production of inducible nitric oxide synthase,
IL-1beta , and TNF-alpha and modulated the expression of proopiomelanocortin, a hypothalamic neuropeptide that is involved in the control of energy homeostasis
Ĺabuzek et al., Neurotoxicology 2010
:
The presented evidence supports the conclusion that
AMPK activated by AICAR is
involved in regulation of ROS and cytokine production (
IL-1 beta , TNF-alpha ( 6h ), IL-10 and TGF-beta ) as well as arginase I and PGC-1alpha expression