◀ Back to CCND1

BRCA1 — CCND1

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Bind Interaction: BRCA1 — CCND1 Wang et al., Oncogene 1997
• IRef Bind_translation Interaction: BRCA1 — CCND1 (affinity chromatography technology) Wang et al., Oncogene 1997
• IRef Biogrid Interaction: CCND1 — BRCA1 (direct interaction, pull down) Wang et al., Oncogene 1997
• IRef Biogrid Interaction: CCND1 — BRCA1 (direct interaction, enzymatic study) Kehn et al., Oncogene 2007*
• IRef Hprd Interaction: CCND1 — BRCA1 (in vitro) Wang et al., Oncogene 1997
• IRef Intact Interaction: BRCA1 — CCND1 (colocalization, confocal microscopy) Kehn et al., Oncogene 2007*
• IRef Intact Interaction: BRCA1 — CCND1 (physical association, anti bait coimmunoprecipitation) Kehn et al., Oncogene 2007*
• IRef Ophid Interaction: BRCA1 — CCND1 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Wang et al., J Biol Chem 2000 (Breast Neoplasms...) : Moreover, ectopic expression of cyclin D1 and Cdk4 can stimulate the Brca1 promoter in an E2F dependent manner, and this is inhibited by coexpression of the p16(INK4a) cyclin dependent kinase inhibitor
Nakuci et al., Exp Cell Res 2006 (Breast Neoplasms) : BRCA1-IRIS regulates cyclin D1 expression in breast cancer cells
Hao et al., Int J Cancer 2007 (Breast Neoplasms) : BRCA1-IRIS activates cyclin D1 expression in breast cancer cells by downregulating the JNK phosphatase DUSP3/VHR
Kehn et al., Oncogene 2007 (Breast Neoplasms) : Using chromatin immunoprecipitation assays, we observed that the inhibition of cyclin D1/cdk4 activity resulted in increased BRCA1 DNA binding at particular promoters in vivo ... Collectively, these results indicate that cyclin D1/cdk4 mediated phosphorylation of BRCA1 inhibits the ability of BRCA1 to be recruited to particular promoters in vivo