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IRF3 — MYD88

Text-mined interactions from Literome

Koide et al., J Endotoxin Res 2007 : LPS significantly augmented the activation of interferon regulatory factor (IRF)-1 in IFN-gamma stimulated END-D cells, although it did not affect the activation of either MyD88 dependent nuclear factor (NF)-kappaB or MyD88 independent IRF-3
Youn et al., Biochem Pharmacol 2008 : Cinnamaldehyde did not inhibit the activation of NFkappaB or IRF3 induced by MyD88 dependent ( MyD88, IKKbeta ) or TRIF dependent ( TRIF, TBK1 ) downstream signaling components
Lee et al., Mol Cells 2008 : Acrolein inhibited NF-kappaB and IRF3 activation by LPS, but it did not inhibit NF-kappaB or IRF3 activation by MyD88 , inhibitor kappaB kinase (IKK)beta, TRIF, or TNF-receptor associated factor family member associated NF-kappaB activator ( TANK) binding kinase 1 (TBK1 )
Wang et al., Nat Immunol 2009 (Rhabdoviridae Infections...) : Knockdown of Nrdp1 inhibited the degradation of MyD88 and the activation of TBK1 and IRF3
Siednienko et al., J Immunol 2011 : Our study offers a new role for MyD88 in restricting TLR3 signaling through a hitherto unknown mechanism whereby MyD88 specifically impairs IKKe mediated induction of IRF3 and concomitant IFN-ß and RANTES production