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CFLAR — DISC2

Text-mined interactions from Literome

Ganten et al., Hepatology 2005 (Carcinoma, Hepatocellular...) : In conclusion, these results show that otherwise chemotherapy-resistant tumor cells can be sensitized for TRAIL induced apoptosis at the DISC level in the presence of high levels of cFLIP , which suggests the existence of an additional factor that modulates the interaction of FADD and the TRAIL death receptors
Walker et al., Mol Pharmacol 2009 (Colonic Neoplasms) : In SW480 cells, sorafenib + vorinostat increased CD95 plasma membrane levels and promoted death inducing signal complex ( DISC ) formation, and drug toxicity was blocked by knockdown of CD95 or overexpression of cellular FLICE-like inhibitory protein ( c-FLIP-s )
Scaffidi et al., J Biol Chem 1999 : In stably transfected BJAB cells, c-FLIP blocks caspase-8 activation at the DISC and thereby inhibits CD95 mediated apoptosis