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IGFBP1 — PRKAR2B
Text-mined interactions from Literome
Frost et al., Endocrinology 2000
:
Conversely, a
PKA inhibitor ( H-89 )
inhibited the ability of cAMP, but not IL-1beta to stimulate
IGFBP-1 synthesis
Whitehouse et al., J Endocrinol 2002
:
We have now investigated the responses to
PKA activation and
inhibition of
PP1/2A and used PTP inhibitors to examine the relationship between the morphological changes and enhanced steroid production
Woo et al., Eur J Neurosci 2002
(Synaptic Transmission) :
Our data show that genetic inhibition of PKA impairs L-LTP by reducing
PKA mediated suppression of
PP1/2A
Yeagley et al., Mol Endocrinol 2005
:
PKA and Dex also synergistically induced a minimal 3 x glucocorticoid response element promoter, but
inhibited Dex induction of the mouse mammary tumor virus and
IGF binding protein 1 promoters, even though PKA alone did not regulate these promoters
Suwanichkul et al., J Biol Chem 1993
(Carcinoma, Hepatocellular...) :
In addition, cotransfection of the catalytic subunit of cAMP dependent protein kinase A (PKA) with the native 1205-bp IGFBP-1 promoter construct stimulated IGFBP-1 promoter activity 3.9-fold, but the TAGCA mutation decreased by 73 % the ability of
PKA to
stimulate IGFBP-1 promoter activity above control levels