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NF2 — RAC3
Text-mined interactions from Literome
Wei et al., J Virol 2005
:
Merlin , a cellular substrate of PAK2, is homologous to the ezrin-radixin-moesin family and
plays a critical role in
Rac signaling
Nakai et al., J Neurosci 2006
:
NF2 is
involved in suppression of
Rac signaling, and cultured schwannoma cells contain elevated, GTP bound, active Rac
Huang et al., Oncogene 2008
(Neurilemmoma...) :
Consistently, VprBP depletion abolished the in vivo interaction of
Merlin and Roc1-Cullin4A-DDB1, which resulted in Merlin stabilization and
inhibited ERK and
Rac activation