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CCL2 — ICAM1

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: Complex of ICAM1-ITGAL-ITGB2 → CCL2 (increases)
  Evidence: Strong adhesion between leukocytes and endothelial cells is promoted by the induction of ICAM-1 on inflamed endothelium and the activation of a conformational change in LFA-1 and Mac-1 in response to chemokines.
• OpenBEL Selventa BEL large corpus: Complex of ICAM1-ITGAM-ITGB2 → CCL2 (increases)
  Evidence: Strong adhesion between leukocytes and endothelial cells is promoted by the induction of ICAM-1 on inflamed endothelium and the activation of a conformational change in LFA-1 and Mac-1 in response to chemokines.

Text-mined interactions from Literome

Kuroiwa et al., J Immunol 1999 (Glomerulonephritis) : Ligation of mesangial surface ICAM-1 directly enhanced IL-6, but not MCP-1 , production
Kitching et al., Clin Exp Immunol 2002 (Glomerulonephritis, Membranoproliferative) : IL-10 treatment resulted in reduced renal IL-1beta mRNA expression and reduced glomerular ICAM-1 expression, but renal expression of MCP-1 and osteopontin mRNA was unaltered
Viedt et al., J Am Soc Nephrol 2002 (Nephritis) : MCP-1 stimulated interleukin-6 (IL-6) secretion and intercellular adhesion molecule-1 ( ICAM-1 ) synthesis in a time- and dose dependent manner ... In parallel, MCP-1 increased IL-6 and ICAM-1 mRNA expression in human TECs ... Pretreatment with pertussis toxin, GF109203X, BAPTA-AM, and pyrrolidine dithiocarbamate inhibited MCP-1 dependent IL-6 and ICAM-1 synthesis, suggesting the involvement of Gi-proteins, protein kinase C, intracellular Ca ( 2+ ), and nuclear factor-kappaB (NF-kappaB) in MCP-1 signaling ... In contrast to IL-6 release, MCP-1 induced ICAM-1 expression was predominantly dependent on NF-kappaB activation
Giunti et al., Kidney Int 2006 : We tested whether MCP-1 binding to CCR2 affects ICAM-1 expression in HMCs and, secondly, if stretch induced ICAM-1 is mediated by MCP-1 via an autocrine mechanism ... HMCs exposure to rh-MCP-1 induced a significant twofold increase in ICAM-1 expression at 24 h, leading to enhanced monocyte adhesion ... In conclusion, stretch and MCP-1 independently induce ICAM-1 expression in HMCs. Stretch induced CCR2 downregulation may favour MCP-1 paracrine activity
Wildgruber et al., Br J Radiol 2007 (Arterial Occlusive Diseases...) : During the 4 weeks after intervention levels of e-selectin, ICAM , VCAM and MCP-1 increased after both angioplasty and cryoplasty
Kawai et al., Cancer Sci 2009 (Breast Neoplasms) : CCL2 caused a selective and significant expression of ICAM-1 on human lymphatic endothelial cells but CCL1, CCL12 and CCL21 did not ... These findings suggest that CCL2 induces selective and significant expression of ICAM-1 on cultured human lymphatic endothelial cells and then facilitates the attachment of carcinoma cells to the lymphatic endothelial cells, thus providing an in vitro micrometastatic model via the overexpression of ICAM-1
Del Papa et al., Arthritis Rheum 1996 (Wegener Granulomatosis) : We found that AECA IgG from WG patients do not display any significant cytotoxicity but are able to up-regulate the expression of E-selectin, intercellular adhesion molecule 1 and vascular cell adhesion molecule 1 and to induce the secretion of IL-1 beta, IL-6, IL-8, and MCP-1 ... We found that AECA IgG from WG patients do not display any significant cytotoxicity but are able to up-regulate the expression of E-selectin, intercellular adhesion molecule 1 and vascular cell adhesion molecule 1 and to induce the secretion of IL-1 beta, IL-6, IL-8, and MCP-1
Yamaguchi et al., Hepatology 1998 (Ischemia) : Monocyte chemoattractant protein-1 enhances expression of intercellular adhesion molecule-1 following ischemia-reperfusion of the liver in rats ... We investigated the effects of monocyte chemoattractant protein-1 ( MCP-1 ) produced by Kupffer cells on ICAM-1 expression after ischemia-reperfusion in rat liver by occluding the portal vein for 30 minutes