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CBL — EPHB2
Text-mined interactions from Literome
McCarty et al., J Recept Signal Transduct Res 1999
:
In contrast, mutation of Y785 does not significantly affect BDNF-inducible Shc phosphorylation,
ERK1/2 activation, or c-fos protein synthesis, but completely
inhibits the tyrosine phosphorylation of PLCgamma and
Cbl
Fong et al., J Biol Chem 2003
(MAP Kinase Signaling System) :
Furthermore, individually mutating hSpry2 residues 52-59 to alanine indicated a tight correlation between their affinity for
c-Cbl binding and their
inhibition of
ERK2 activity in the FGFR pathway
Zhang et al., J Immunol 2004
(Calcium Signaling...) :
The absence of
c-Cbl increased the phosphorylation of
ERK after receptor stimulation, but resulted in slightly reduced p38 phosphorylation and Ca ( 2+ ) response
Gustin et al., J Immunol 2006
:
However, loss of
Cbl-b does not
enhance the activation of
ERK or Akt, nor does it promote a greater calcium response
Qu et al., FEBS Lett 2009
(Cell Transformation, Neoplastic...) :
Moreover, overexpression of
Cbl-b significantly suppressed ERK activation, and Cbl-b ( DN ) strongly
enhanced both
ERK and Akt activation
Eisinger et al., J Biol Chem 2009
(MAP Kinase Signaling System) :
Conversely, overexpression of c-Src as well as down-regulation of
c-Cbl by small interfering RNA
results in persistent etorphine induced stimulation of
ERK1/2 activity
Qu et al., Mol Cell Biochem 2010
(Leukemia, Basophilic, Acute) :
On the other hand,
ERK activity was
enhanced by
Cbl-b , and the ERK inhibitor PD98059 reversed Cbl-b enhanced apoptosis
Sévère et al., J Biol Chem 2011
:
Analysis of molecular mechanisms revealed that the
Cbl mutant
increased PDGF receptor a and FGF receptor 2 but not EGF receptor expression in hMSCs, resulting in increased
ERK1/2 and PI3K signaling
Li et al., Mol Med Report 2011
(Lung Neoplasms) :
Cbl regulated Akt and
ERK signals are involved in ß-elemene induced cell apoptosis in lung cancer cells
Yan et al., J Cancer Res Clin Oncol 2012
(Breast Neoplasms...) :
Moreover, down-regulation of
Cbl-b by shRNA
led to stronger activation of
ERK , JNK and p38 MAPK, more up-regulation of DR4 and DR5, and a stronger synergistic effect of bufalin and TRAIL
Samoylenko et al., Carcinogenesis 2012
(Adenocarcinoma...) :
Thereby, Ruk ( l )
/CIN85 led to a more rapid and prolonged epidermal growth factor dependent activation of Src, Akt and
ERK1/2 and treatment with the Src inhibitor PP2 and the PI3K inhibitor LY294002 abolished the Ruk ( l ) /CIN85 dependent changes in cell motility
Miranti et al., Curr Biol 1998
:
This pathway may regulate multiple downstream events in hematopoietic cells, including Rac induced lamellipodia formation, tyrosine phosphorylation of
Cbl , and
activation of JNK,
ERK2 and the phosphatidylinositol 3'-kinase regulated kinase Akt