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AHR — IL2
Text-mined interactions from Literome
Jeon et al., J Immunol 2000
:
We had previously shown that activation of the
arylhydrocarbon receptor (AHR) , a member of the bHLH-PAS family of transcription factors,
leads to increased mRNA expression of
IL-2 in murine fetal thymocytes ... The
IL-2 gene can be
induced by the
AHR also in thymocytes in vivo after injection of 2,3,7, 8-tetrachlorodibenzo-p-dioxin, a potent ligand of the AHR ... The
AHR mediates the
IL-2 induction as shown with AHR-deficient mice
Ishikawa et al., Int Immunol 2006
(Asthma...) :
Thus, we examined the capacity of
IL-2 and IL-18 to
induce AHR , airway eosinophilic inflammation and goblet cell metaplasia