◀ Back to MAPK7

MAPK7 — MEF2C

Pathways - manually collected, often from reviews:

• BioCarta control of skeletal myogenesis by hdac and calcium/calmodulin-dependent kinase (camk): ERK5 (MAPK7) → MEF2/MYOD complex (MYOD1-MEF2C_MEF2B_MEF2D_MEF2A) (transcription, activates)
  
• Reactome Reaction: MEF2C → MAPK7 (reaction)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Bind_translation Interaction: MAPK7 — MEF2C (experimental interaction detection) Huang et al., Biochem Biophys Res Commun 2003*
• IRef Biogrid Interaction: MAPK7 — MEF2C (direct interaction, pull down) Yang et al., Nucleic Acids Res 1998*
• IRef Biogrid Interaction: MAPK7 — MEF2C (direct interaction, enzymatic study) Yang et al., Nucleic Acids Res 1998*
• IRef Biogrid Interaction: MAPK7 — MEF2C (direct interaction, two hybrid) Bandyopadhyay et al., Nat Methods 2010
• IRef Hprd Interaction: MEF2C — MAPK7 (in vitro) Kato et al., EMBO J 1997*, Yang et al., Nucleic Acids Res 1998*
• IRef Hprd Interaction: MEF2C — MAPK7 (in vivo) Kato et al., EMBO J 1997*, Yang et al., Nucleic Acids Res 1998*
• IRef Intact Interaction: MAPK7 — MEF2C (physical association, two hybrid pooling approach) Bandyopadhyay et al., Nat Methods 2010
• IRef Ophid Interaction: MAPK7 — MEF2C (aggregation, confirmational text mining) Yang et al., Nucleic Acids Res 1998*
• IRef Ophid Interaction: MAPK7 — MEF2C (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Cavanaugh et al., J Neurosci 2001 : In contrast to ERK1/2, ERK5 strongly activated the transcriptional activity of myocyte enhancer factor 2C (MEF2C) in pheochromocytoma 12 ( PC12 ) cells and was required for neurotrophin stimulation of MEF2C transcription in both PC12 cells and cortical neurons
Ding et al., Stem Cells Dev 2008 : Nuclear location of MEF2C , which played a critical role in cardiomyocyte differentiation and could be activated by p38MAPK , was stimulated after icariin exposure
Andrews et al., Eur J Immunol 2012 : The transcription factor myocyte enhancer factor-2C (MEF2C) is regulated by both calcineurin and mitogen activated protein kinase signaling pathways, and is essential for proliferation and survival downstream of BCR engagement in mature B cells
Kato et al., EMBO J 1997 : BMK1 dramatically enhances the transactivation activity of MEF2C by phosphorylating a serine residue at amino acid position 387 in this transcription factor ... Serum is also a potent stimulator of BMK1 induced MEF2C phosphorylation, since a dominant negative form of BMK1 specifically inhibits serum induced activation of MEF2C