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ITGA6 — ITGB1

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: PRKCA → Complex of ITGA6-ITGB1 (increases, ITGA6/ITGB1 Activity, PRKCA Activity) Chung et al., Cancer Res 2004*
  Evidence: The results obtained indicate that alpha6beta1 is necessary for VEGF expression because the ability of hypoxia to activate HIF-1 and to stimulate VEGF transcription in MDA-MB-435 cells is dependent on alpha6beta1 expression by a mechanism that involves protein kinase C-alpha.
• KEGG Focal adhesion: ACTN1/ACTN2/ACTN3/ACTN4 → Complex of 21 proteins (protein-protein, binding/association)
• KEGG Focal adhesion: FLNA/FLNB/FLNC → Complex of 21 proteins (protein-protein, binding/association)
• KEGG Focal adhesion: TLN1/TLN2 → Complex of 21 proteins (protein-protein, binding/association)
• KEGG Focal adhesion: PXN → Complex of 21 proteins (protein-protein, binding/association)
• KEGG Focal adhesion: VASP → Complex of 21 proteins (protein-protein, binding/association)
• KEGG Focal adhesion: PARVA/PARVB/PARVG → Complex of 21 proteins (protein-protein, binding/association)
• KEGG Focal adhesion: CHAD/COL11A1/COL11A2/COL1A1/COL1A2/COL2A1/COL3A1/COL4A1/COL4A2/COL4A4/COL4A5/COL4A6/COL5A1/COL5A2/COL5A3/COL6A1/COL6A2/COL6A3/COL6A6/COMP/FN1/IBSP/LAMA1/LAMA2/LAMA3/LAMA4/LAMA5/LAMB1/LAMB2/LAMB3/LAMB4/LAMC1/LAMC2/LAMC3/RELN/SPP1/THBS1/THBS2/THBS3/THBS4/TNC/TNN/TNR/TNXB/VTN/VWF → Complex of 21 proteins (protein-protein, activation)
• KEGG ECM-receptor interaction: LAMA1/LAMA2/LAMA3/LAMA4/LAMA5/LAMB1/LAMB2/LAMB3/LAMB4/LAMC1/LAMC2/LAMC3 → Complex of ITGA6-ITGB1 (protein-protein, activation)
• KEGG Pathways in cancer: COL4A1/COL4A2/COL4A4/COL4A5/COL4A6/FN1/LAMA1/LAMA2/LAMA3/LAMA4/LAMA5/LAMB1/LAMB2/LAMB3/LAMB4/LAMC1/LAMC2/LAMC3 → Complex of ITGA2-ITGA2B-ITGA3-ITGA6-ITGAV-ITGB1 (protein-protein, activation)
  
• KEGG Pathways in cancer: Complex of ITGA2-ITGA2B-ITGA3-ITGA6-ITGAV-ITGB1 → PTK2 (protein-protein, activation)
• KEGG Small cell lung cancer: COL4A1/COL4A2/COL4A4/COL4A5/COL4A6/FN1/LAMA1/LAMA2/LAMA3/LAMA4/LAMA5/LAMB1/LAMB2/LAMB3/LAMB4/LAMC1/LAMC2/LAMC3 → Complex of ITGA2-ITGA2B-ITGA3-ITGA6-ITGAV-ITGB1 (protein-protein, activation)
  
• KEGG Small cell lung cancer: Complex of ITGA2-ITGA2B-ITGA3-ITGA6-ITGAV-ITGB1 → PTK2 (protein-protein, activation)
• KEGG Dilated cardiomyopathy: Complex of 21 proteins → ACTB/ACTG1 (protein-protein, binding/association)
• NCI Pathway Database Beta1 integrin cell surface interactions: alpha6/beta1 Integrin/Thrombospondin complex (ITGA6-ITGB1-THBS1) → alpha6/beta1 Integrin complex (ITGA6-ITGB1) (modification, collaborate)
  Calzada et al., J Biol Chem 2003*
  Evidence: physical interaction
• NCI Pathway Database Beta1 integrin cell surface interactions: alpha6/beta1 Integrin/Thrombospondin complex (ITGA6-ITGB1-THBS1) → Thrombospondin complex (THBS1) (modification, collaborate)
  Calzada et al., J Biol Chem 2003*
  Evidence: physical interaction
• NCI Pathway Database Beta1 integrin cell surface interactions: alpha6/beta1 Integrin complex (ITGA6-ITGB1) → Thrombospondin complex (THBS1) (modification, collaborate)
  Calzada et al., J Biol Chem 2003*
  Evidence: physical interaction
• NCI Pathway Database Beta1 integrin cell surface interactions: alpha6/beta1 Integrin/Laminin 11 complex (ITGA6-ITGB1-LAMA5-LAMC1-LAMB2) → Laminin 11 complex (LAMA5-LAMB2-LAMC1) (modification, collaborate)
  Kikkawa et al., J Cell Sci 2000, Ferletta et al., Mol Biol Cell 2003, Nishiuchi et al., J Biochem 2003, Nishiuchi et al., Matrix Biol 2006
  Evidence: physical interaction
• NCI Pathway Database Beta1 integrin cell surface interactions: alpha6/beta1 Integrin/Laminin 11 complex (ITGA6-ITGB1-LAMA5-LAMC1-LAMB2) → alpha6/beta1 Integrin complex (ITGA6-ITGB1) (modification, collaborate)
  Kikkawa et al., J Cell Sci 2000, Ferletta et al., Mol Biol Cell 2003, Nishiuchi et al., J Biochem 2003, Nishiuchi et al., Matrix Biol 2006
  Evidence: physical interaction
• NCI Pathway Database Beta1 integrin cell surface interactions: Laminin 11 complex (LAMA5-LAMB2-LAMC1) → alpha6/beta1 Integrin complex (ITGA6-ITGB1) (modification, collaborate)
  Kikkawa et al., J Cell Sci 2000, Ferletta et al., Mol Biol Cell 2003, Nishiuchi et al., J Biochem 2003, Nishiuchi et al., Matrix Biol 2006
  Evidence: physical interaction
• NCI Pathway Database Beta1 integrin cell surface interactions: Laminin 1 complex (LAMA1-LAMB1-LAMC1) → alpha6/beta1 Integrin complex (ITGA6-ITGB1) (modification, collaborate)
  Ferletta et al., Mol Biol Cell 2003, Tate et al., Mol Cell Neurosci 2004, Maschler et al., Oncogene 2005, Nishiuchi et al., Matrix Biol 2006, Sonnenberg et al., J Cell Biol 1990, Lange et al., Exp Cell Res 1994, Shaw et al., J Biol Chem 1995, Chang et al., J Immunol 1995, Delwel et al., Mol Biol Cell 1994, Delwel et al., J Biol Chem 1996, De Melker et al., Eur J Biochem 1996, Dogic et al., J Cell Sci 1998, Wei et al., J Biol Chem 1998
  Evidence: physical interaction
• NCI Pathway Database Beta1 integrin cell surface interactions: Laminin 1 complex (LAMA1-LAMB1-LAMC1) → alpha6/beta1 Integrin/Laminin 1 complex (ITGA6-ITGB1-LAMA1-LAMC1-LAMB1) (modification, collaborate)
  Ferletta et al., Mol Biol Cell 2003, Tate et al., Mol Cell Neurosci 2004, Maschler et al., Oncogene 2005, Nishiuchi et al., Matrix Biol 2006, Sonnenberg et al., J Cell Biol 1990, Lange et al., Exp Cell Res 1994, Shaw et al., J Biol Chem 1995, Chang et al., J Immunol 1995, Delwel et al., Mol Biol Cell 1994, Delwel et al., J Biol Chem 1996, De Melker et al., Eur J Biochem 1996, Dogic et al., J Cell Sci 1998, Wei et al., J Biol Chem 1998
  Evidence: physical interaction
• NCI Pathway Database Beta1 integrin cell surface interactions: alpha6/beta1 Integrin complex (ITGA6-ITGB1) → alpha6/beta1 Integrin/Laminin 1 complex (ITGA6-ITGB1-LAMA1-LAMC1-LAMB1) (modification, collaborate)
  Ferletta et al., Mol Biol Cell 2003, Tate et al., Mol Cell Neurosci 2004, Maschler et al., Oncogene 2005, Nishiuchi et al., Matrix Biol 2006, Sonnenberg et al., J Cell Biol 1990, Lange et al., Exp Cell Res 1994, Shaw et al., J Biol Chem 1995, Chang et al., J Immunol 1995, Delwel et al., Mol Biol Cell 1994, Delwel et al., J Biol Chem 1996, De Melker et al., Eur J Biochem 1996, Dogic et al., J Cell Sci 1998, Wei et al., J Biol Chem 1998
  Evidence: physical interaction
• NCI Pathway Database Beta1 integrin cell surface interactions: alpha6/beta1 Integrin/Laminin 4 complex (ITGA6-ITGB1-LAMA2-LAMC1-LAMB2) → Laminin 4 complex (LAMA2-LAMB2-LAMC1) (modification, collaborate)
  Delwel et al., Mol Biol Cell 1994
  Evidence: physical interaction
• NCI Pathway Database Beta1 integrin cell surface interactions: alpha6/beta1 Integrin/Laminin 4 complex (ITGA6-ITGB1-LAMA2-LAMC1-LAMB2) → alpha6/beta1 Integrin complex (ITGA6-ITGB1) (modification, collaborate)
  Delwel et al., Mol Biol Cell 1994
  Evidence: physical interaction
• NCI Pathway Database Beta1 integrin cell surface interactions: Laminin 4 complex (LAMA2-LAMB2-LAMC1) → alpha6/beta1 Integrin complex (ITGA6-ITGB1) (modification, collaborate)
  Delwel et al., Mol Biol Cell 1994
  Evidence: physical interaction
• NCI Pathway Database a6b1 and a6b4 Integrin signaling: ErbB2 (ERBB2) → alpha6/beta1 Integrin complex (ITGA6-ITGB1) (proteasomal ubiquitin-dependent protein catabolic process, collaborate)
  Shimizu et al., Oncogene 2003*
  Evidence: assay
• NCI Pathway Database Beta1 integrin cell surface interactions: alpha6/beta1 Integrin/Midkine complex (MDK-ITGA6-ITGB1) → alpha6/beta1 Integrin complex (ITGA6-ITGB1) (modification, collaborate)
  Muramatsu et al., J Cell Sci 2004*
  Evidence: physical interaction
• NCI Pathway Database Beta1 integrin cell surface interactions: alpha6/beta1 Integrin/Midkine complex (MDK-ITGA6-ITGB1) → Midkine (MDK) (modification, collaborate) Muramatsu et al., J Cell Sci 2004*
  Evidence: physical interaction
• NCI Pathway Database Beta1 integrin cell surface interactions: alpha6/beta1 Integrin complex (ITGA6-ITGB1) → Midkine (MDK) (modification, collaborate) Muramatsu et al., J Cell Sci 2004*
  Evidence: physical interaction
• NCI Pathway Database Beta1 integrin cell surface interactions: alpha6/beta1 Integrin/Laminin 6 complex (ITGA6-ITGB1-LAMA3-LAMC1-LAMB1) → alpha6/beta1 Integrin complex (ITGA6-ITGB1) (modification, collaborate)
  Hirosaki et al., J Biol Chem 2002, Shaw et al., J Biol Chem 1995, Delwel et al., Mol Biol Cell 1994
  Evidence: physical interaction
• NCI Pathway Database Beta1 integrin cell surface interactions: alpha6/beta1 Integrin/Laminin 6 complex (ITGA6-ITGB1-LAMA3-LAMC1-LAMB1) → Laminin 6 complex (LAMA3-LAMB1-LAMC1) (modification, collaborate)
  Hirosaki et al., J Biol Chem 2002, Shaw et al., J Biol Chem 1995, Delwel et al., Mol Biol Cell 1994
  Evidence: physical interaction
• NCI Pathway Database Beta1 integrin cell surface interactions: alpha6/beta1 Integrin complex (ITGA6-ITGB1) → Laminin 6 complex (LAMA3-LAMB1-LAMC1) (modification, collaborate)
  Hirosaki et al., J Biol Chem 2002, Shaw et al., J Biol Chem 1995, Delwel et al., Mol Biol Cell 1994
  Evidence: physical interaction
• NCI Pathway Database Beta1 integrin cell surface interactions: alpha6/beta1 Integrin/Thrombospondin-2 complex (ITGA6-ITGB1-THBS2) → Thrombospondin-2 complex (THBS2) (modification, collaborate)
  Calzada et al., J Biol Chem 2003*
  Evidence: physical interaction
• NCI Pathway Database Beta1 integrin cell surface interactions: alpha6/beta1 Integrin/Thrombospondin-2 complex (ITGA6-ITGB1-THBS2) → alpha6/beta1 Integrin complex (ITGA6-ITGB1) (modification, collaborate)
  Calzada et al., J Biol Chem 2003*
  Evidence: physical interaction
• NCI Pathway Database Beta1 integrin cell surface interactions: Thrombospondin-2 complex (THBS2) → alpha6/beta1 Integrin complex (ITGA6-ITGB1) (modification, collaborate)
  Calzada et al., J Biol Chem 2003*
  Evidence: physical interaction
• NCI Pathway Database Beta1 integrin cell surface interactions: alpha6/beta1 Integrin/Laminin 10 complex (ITGA6-ITGB1-LAMA5-LAMC1-LAMB1) → alpha6/beta1 Integrin complex (ITGA6-ITGB1) (modification, collaborate)
  Kikkawa et al., J Cell Sci 2000, Ferletta et al., Mol Biol Cell 2003, Nishiuchi et al., J Biochem 2003, Ido et al., J Biol Chem 2004, Nishiuchi et al., Matrix Biol 2006
  Evidence: physical interaction
• NCI Pathway Database Beta1 integrin cell surface interactions: alpha6/beta1 Integrin/Laminin 10 complex (ITGA6-ITGB1-LAMA5-LAMC1-LAMB1) → Laminin 10 complex (LAMA5-LAMB1-LAMC1) (modification, collaborate)
  Kikkawa et al., J Cell Sci 2000, Ferletta et al., Mol Biol Cell 2003, Nishiuchi et al., J Biochem 2003, Ido et al., J Biol Chem 2004, Nishiuchi et al., Matrix Biol 2006
  Evidence: physical interaction
• NCI Pathway Database Beta1 integrin cell surface interactions: alpha6/beta1 Integrin complex (ITGA6-ITGB1) → Laminin 10 complex (LAMA5-LAMB1-LAMC1) (modification, collaborate)
  Kikkawa et al., J Cell Sci 2000, Ferletta et al., Mol Biol Cell 2003, Nishiuchi et al., J Biochem 2003, Ido et al., J Biol Chem 2004, Nishiuchi et al., Matrix Biol 2006
  Evidence: physical interaction
• NCI Pathway Database a6b1 and a6b4 Integrin signaling: alpha6/beta4 Integrin complex (ITGA6-ITGB4) → beta1 Integrin (ITGB1) (modification, collaborate)
  Evidence: assay
• NCI Pathway Database a6b1 and a6b4 Integrin signaling: alpha6/beta4 Integrin complex (ITGA6-ITGB4) → alpha6/beta1 Integrin complex (ITGA6-ITGB1) (modification, collaborate)
  
  Evidence: assay
• NCI Pathway Database a6b1 and a6b4 Integrin signaling: alpha6 Integrin (ITGA6) → beta1 Integrin (ITGB1) (modification, collaborate)
  Evidence: assay
• NCI Pathway Database a6b1 and a6b4 Integrin signaling: alpha6 Integrin (ITGA6) → alpha6/beta1 Integrin complex (ITGA6-ITGB1) (modification, collaborate)
  
  Evidence: assay
• NCI Pathway Database a6b1 and a6b4 Integrin signaling: beta1 Integrin (ITGB1) → alpha6/beta1 Integrin complex (ITGA6-ITGB1) (modification, collaborate)
  
  Evidence: assay
• NCI Pathway Database a6b1 and a6b4 Integrin signaling: alpha6/beta1 Integrin complex (ITGA6-ITGB1) → beta4 Integrin (ITGB4) (modification, collaborate)
  Evidence: assay
• NCI Pathway Database a6b1 and a6b4 Integrin signaling: Laminin (LAMA3/LAMB3/LAMC2/LAMA5/LAMB2/LAMC1/LAMA2/LAMB2/LAMC1/LAMA3/LAMB1/LAMC1/LAMA1/LAMB1/LAMC1/LAMA5/LAMB1/LAMC1/LAMA2/LAMB1/LAMC1/LAMA4/LAMB1/LAMC1) → alpha6/beta1 Integrin complex (ITGA6-ITGB1) (modification, collaborate)
  Nielsen et al., J Biol Chem 2001, Lee et al., J Cell Biol 1992, Sonnenberg et al., Exp Cell Res 1991, Niessen et al., Exp Cell Res 1994
  Evidence: assay
• NCI Pathway Database a6b1 and a6b4 Integrin signaling: Laminin (LAMA3/LAMB3/LAMC2/LAMA5/LAMB2/LAMC1/LAMA2/LAMB2/LAMC1/LAMA3/LAMB1/LAMC1/LAMA1/LAMB1/LAMC1/LAMA5/LAMB1/LAMC1/LAMA2/LAMB1/LAMC1/LAMA4/LAMB1/LAMC1) → alpha6/beta1 Integrin/Laminin complex (ITGA6-ITGB1) (modification, collaborate)
  Nielsen et al., J Biol Chem 2001, Lee et al., J Cell Biol 1992, Sonnenberg et al., Exp Cell Res 1991, Niessen et al., Exp Cell Res 1994
  Evidence: assay
• NCI Pathway Database a6b1 and a6b4 Integrin signaling: alpha6/beta1 Integrin complex (ITGA6-ITGB1) → alpha6/beta1 Integrin/Laminin complex (ITGA6-ITGB1) (modification, collaborate)
  Nielsen et al., J Biol Chem 2001, Lee et al., J Cell Biol 1992, Sonnenberg et al., Exp Cell Res 1991, Niessen et al., Exp Cell Res 1994
  Evidence: assay
• NCI Pathway Database Beta1 integrin cell surface interactions: Laminin 2 complex (LAMA2-LAMB1-LAMC1) → alpha6/beta1 Integrin/Laminin 2 complex (ITGA6-ITGB1-LAMA2-LAMC1-LAMB1) (modification, collaborate)
  Iwao et al., Immunology 2000, Chang et al., J Immunol 1995
  Evidence: physical interaction
• NCI Pathway Database Beta1 integrin cell surface interactions: Laminin 2 complex (LAMA2-LAMB1-LAMC1) → alpha6/beta1 Integrin complex (ITGA6-ITGB1) (modification, collaborate)
  Iwao et al., Immunology 2000, Chang et al., J Immunol 1995
  Evidence: physical interaction
• NCI Pathway Database Beta1 integrin cell surface interactions: alpha6/beta1 Integrin/Laminin 2 complex (ITGA6-ITGB1-LAMA2-LAMC1-LAMB1) → alpha6/beta1 Integrin complex (ITGA6-ITGB1) (modification, collaborate)
  Iwao et al., Immunology 2000, Chang et al., J Immunol 1995
  Evidence: physical interaction
• NCI Pathway Database Beta1 integrin cell surface interactions: alpha6/beta1 Integrin/Laminin 5 complex (ITGA6-ITGB1-LAMA3-LAMC2-LAMB3) → Laminin 5 complex (LAMA3-LAMB3-LAMC2) (modification, collaborate)
  DiPersio et al., J Cell Sci 2000, Nishiuchi et al., Matrix Biol 2006, Delwel et al., Mol Biol Cell 1994
  Evidence: physical interaction
• NCI Pathway Database Beta1 integrin cell surface interactions: alpha6/beta1 Integrin/Laminin 5 complex (ITGA6-ITGB1-LAMA3-LAMC2-LAMB3) → alpha6/beta1 Integrin complex (ITGA6-ITGB1) (modification, collaborate)
  DiPersio et al., J Cell Sci 2000, Nishiuchi et al., Matrix Biol 2006, Delwel et al., Mol Biol Cell 1994
  Evidence: physical interaction
• NCI Pathway Database Beta1 integrin cell surface interactions: Laminin 5 complex (LAMA3-LAMB3-LAMC2) → alpha6/beta1 Integrin complex (ITGA6-ITGB1) (modification, collaborate)
  DiPersio et al., J Cell Sci 2000, Nishiuchi et al., Matrix Biol 2006, Delwel et al., Mol Biol Cell 1994
  Evidence: physical interaction
• NCI Pathway Database a6b1 and a6b4 Integrin signaling: CD9 (CD9) → alpha6/beta1 Integrin complex (ITGA6-ITGB1) (modification, collaborate)
  Takao et al., Mol Hum Reprod 1999*, Park et al., Mol Hum Reprod 2000*
  Evidence: physical interaction
• NCI Pathway Database a6b1 and a6b4 Integrin signaling: CD9 (CD9) → alpha6/beta1 Integrin/CD9 complex (ITGA6-CD9-ITGB1) (modification, collaborate)
  Takao et al., Mol Hum Reprod 1999*, Park et al., Mol Hum Reprod 2000*
  Evidence: physical interaction
• NCI Pathway Database a6b1 and a6b4 Integrin signaling: alpha6/beta1 Integrin complex (ITGA6-ITGB1) → alpha6/beta1 Integrin/CD9 complex (ITGA6-CD9-ITGB1) (modification, collaborate)
  Takao et al., Mol Hum Reprod 1999*, Park et al., Mol Hum Reprod 2000*
  Evidence: physical interaction
• NCI Pathway Database Beta1 integrin cell surface interactions: alpha6/beta1 Integrin/Laminin 8 complex (ITGA6-ITGB1-LAMA4-LAMC1-LAMB1) → Laminin 8 complex (LAMA4-LAMB1-LAMC1) (modification, collaborate)
  Geberhiwot et al., Exp Cell Res 1999, Geberhiwot et al., J Cell Sci 2001, Fujiwara et al., J Biol Chem 2001
  Evidence: physical interaction
• NCI Pathway Database Beta1 integrin cell surface interactions: alpha6/beta1 Integrin/Laminin 8 complex (ITGA6-ITGB1-LAMA4-LAMC1-LAMB1) → alpha6/beta1 Integrin complex (ITGA6-ITGB1) (modification, collaborate)
  Geberhiwot et al., Exp Cell Res 1999, Geberhiwot et al., J Cell Sci 2001, Fujiwara et al., J Biol Chem 2001
  Evidence: physical interaction
• NCI Pathway Database Beta1 integrin cell surface interactions: Laminin 8 complex (LAMA4-LAMB1-LAMC1) → alpha6/beta1 Integrin complex (ITGA6-ITGB1) (modification, collaborate)
  Geberhiwot et al., Exp Cell Res 1999, Geberhiwot et al., J Cell Sci 2001, Fujiwara et al., J Biol Chem 2001
  Evidence: physical interaction
• Reactome Reaction: ITGA6 → ITGB1 (direct_complex)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Bind Interaction: ITGA6 — ITGB1 Bodary et al., J Biol Chem 1990*, Sonnenberg et al., J Cell Biol 1990, Vogel et al., J Biol Chem 1990, Hemler et al., J Biol Chem 1989*, Hemler et al., J Biol Chem 1988*
• IRef Bind_translation Interaction: ITGA6 — ITGB1 (coimmunoprecipitation) Hemler et al., J Biol Chem 1989*
• IRef Biogrid Interaction: ITGB1 — ITGA6 (physical association, affinity chromatography technology) Zhang et al., Hepatology 2003*
• IRef Biogrid Interaction: ITGB1 — ITGA6 (physical association, affinity chromatography technology) Schaapveld et al., J Cell Biol 1998*
• MIPS CORUM ITGA6-ITGB1-CD151 complex: ITGA6-ITGB1-CD151 complex complex (CD151-ITGA6-ITGB1) Sterk et al., J Cell Sci 2002*
• MIPS CORUM ITGA6-ITGB1 complex: ITGA6-ITGB1 complex complex (ITGA6-ITGB1) Hemler et al., J Biol Chem 1989*
• MIPS CORUM ITGA6-ITGB1-CYR61 complex: ITGA6-ITGB1-CYR61 complex complex (CYR61-ITGA6-ITGB1) Leu et al., J Biol Chem 2003*
• IRef Corum Interaction: Complex of ITGB1-ITGA6-CD151 (association, coimmunoprecipitation) Sterk et al., J Cell Sci 2002*
• IRef Corum Interaction: Complex of ITGA6-ITGB1-CYR61 (association, affinity chromatography technology) Leu et al., J Biol Chem 2003*
• IRef Corum Interaction: ITGB1 — ITGA6 (association, affinity chromatography technology) Hemler et al., J Biol Chem 1989*
• Gene Ontology Complexes integrin complex: integrin complex complex (ITGAX-ITGB1-ITGB2-ITGB5-ITGB7-ITGB6-ITGA9-ITGA2B-ITGA2-ITGA3-ITGA4-ITGAV-ITGA10-ITGA8-ITGA6-ITGB8-ITGA1-ITGA11-ITGAD-ITGAE) Lehnert et al., Genomics 1999, Camenisch et al., J Biol Chem 2002, Antonov et al., Am J Pathol 2004, Moyle et al., J Biol Chem 1991, Kang et al., The journal of physical chemistry. B 2010, Schnapp et al., J Cell Sci 1995, Shaw et al., J Biol Chem 1994, Palmer et al., J Cell Biol 1993, Briesewitz et al., J Biol Chem 1993, Shang et al., J Immunol 1998, Camper et al., J Biol Chem 1998
• IRef Hprd Interaction: Complex of CD9-CD9-ITGA6-ITGA6-ITGB1-ITGA6-CD9-ITGB1-ITGB1 (in vivo) Schmidt et al., J Neurosci Res 1996*
• IRef Hprd Interaction: Complex of ITGA6-CD151-ITGA6-CD151-ITGB1-ITGA6-CD151-ITGB1-ITGB1 (in vivo) Sterk et al., J Cell Sci 2002*
• IRef Hprd Interaction: Complex of ITGA6-CD63-ITGA6-ITGA6-CD63-ITGB1-CD63-ITGB1-ITGB1 (in vivo) Berditchevski et al., J Biol Chem 1997
• IRef Hprd Interaction: Complex of 19 proteins (in vivo) Berditchevski et al., J Biol Chem 1997
• IRef Hprd Interaction: ITGA6 — ITGB1 (in vivo) Nishida et al., Biochem Biophys Res Commun 1997*
• IRef Intact Interaction: Complex of 25 proteins (association, anti bait coimmunoprecipitation) Mazurov et al., FEBS J 2013
• IRef Intact Interaction: ITGB1 — ITGA6 (direct interaction, inferred by curator) Hermjakob et al., Nucleic Acids Res 2004
• IRef Intact Interaction: ITGB1 — ITGA6 (physical association, immunodepleted coimmunoprecipitation) Hemler et al., J Biol Chem 1989*
• IRef Ophid Interaction: ITGB1 — ITGA6 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005
• IRef Ophid Interaction: ITGB1 — ITGA6 (aggregation, confirmational text mining) Schmidt et al., J Neurosci Res 1996*

Text-mined interactions from Literome

Laplantine et al., J Cell Sci 2000 : In contrast, on other laminin isoforms the adhesion complexes are alpha 3 beta 1 integrin-specific due to a transdominant regulation of the alpha 6 beta 1 integrin by the alpha 3 beta 1 integrin
Casey et al., Clin Exp Metastasis 2000 (Ovarian Neoplasms) : Blocking antibodies against alpha integrin subunits suggest that ovarian carcinoma cell migration toward fibronectin is primarily mediated by the alpha5beta1 integrin, type IV collagen by the alpha2beta1 integrin , and laminin by the alpha6beta1 integrin ... Blocking antibodies against alpha integrin subunits suggest that ovarian carcinoma cell migration toward fibronectin is primarily mediated by the alpha5beta1 integrin , type IV collagen by the alpha2beta1 integrin, and laminin by the alpha6beta1 integrin
Sawai et al., Pancreas 2001 (Neoplasm Metastasis...) : In pancreatic cancer, the enhancement of alpha(6)beta(1) integrin by IL-1alpha through IL-1 receptor type I, as well as the expression of alpha(6)beta(1) integrin, plays an important role in metastasis formation
Sawai et al., J Surg Oncol 2003 (Carcinoma, Ductal, Breast...) : The enhancement of alpha6beta1-integrin by Il-1alpha acting through IL-1RI, as well as the expression of alpha6beta1-integrin, plays an important role in metastasis formation in pancreatic cancer
Sawai et al., Oncology 2003 (Liver Neoplasms...) : In pancreatic cancer, IL-1alpha enhanced alpha(6)beta(1)-integrin expression, probably via increased IL-1RI levels
Chung et al., Cancer Res 2004 (Breast Neoplasms) : Hypoxia induced vascular endothelial growth factor transcription and protection from apoptosis are dependent on alpha6beta1 integrin in breast carcinoma cells
Sawai et al., BMC cell biology 2006 (Carcinoma, Pancreatic Ductal...) : Based on these findings, we conclude that IL-1alpha can induce selective upregulation of alpha6beta1-integrin and uPA/uPAR in pancreatic cancer cells and these changes may modulate the aggressive functions of pancreatic cancer
Grzesiak et al., Surgery 2007 (Pancreatic Neoplasms) : Growth studies showed further that CXCR4 expression on Ln-1 was mediated by the alpha(6)beta(1) integrin whereas IL-8 expression was mediated by both the alpha ( 6 ) beta ( 1 ) and alpha ( 3 ) beta ( 1 ) integrins
van den Berg et al., Proc Natl Acad Sci U S A 2009 (Neovascularization, Pathologic) : asTF-alphaVbeta3 integrin interaction induces endothelial cell migration, whereas asTF dependent formation of capillaries in vitro is dependent on alpha6beta1 integrin
Chai et al., Int J Mol Med 2010 : Upon activation, Rac1 increased surface alpha6/beta1 integrin levels and promoted colony forming efficiency of ESCs