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HDAC1 — STAT3
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Bind Interaction:
STAT3
—
HDAC1
Yuan et al., Science 2005*
-
IRef Bind_translation Interaction:
STAT3
—
HDAC1
(experimental interaction detection)
Yuan et al., Science 2005*
-
IRef Bind_translation Interaction:
STAT3
—
HDAC1
(coimmunoprecipitation)
Yuan et al., Science 2005*
-
IRef Biogrid Interaction:
HDAC1
—
STAT3
(physical association, affinity chromatography technology)
Yang et al., FEBS Lett 2012*
-
IRef Biogrid Interaction:
HDAC1
—
STAT3
(colocalization, imaging technique)
Yang et al., FEBS Lett 2012*
-
IRef Biogrid Interaction:
HDAC1
—
STAT3
(physical association, affinity chromatography technology)
Zhang et al., Proc Natl Acad Sci U S A 2005*
-
IRef Biogrid Interaction:
HDAC1
—
STAT3
(physical association, affinity chromatography technology)
Yuan et al., Science 2005*
-
IRef Biogrid Interaction:
HDAC1
—
STAT3
(physical association, affinity chromatography technology)
Gupta et al., Leukemia 2012*
-
IRef Hprd Interaction:
STAT3
—
HDAC1
(in vivo)
Yuan et al., Science 2005*
-
IRef Intact Interaction:
STAT3
—
HDAC1
(physical association, anti bait coimmunoprecipitation)
Yang et al., FEBS Lett 2012*
Text-mined interactions from Literome
Ochrietor et al., Cytokine 2000
:
Role of
STAT3 and C/EBP in cytokine dependent expression of the mouse
serum amyloid P-component (SAP) and C-reactive protein (CRP) genes
Ray et al., Nucleic Acids Res 2008
:
Interestingly, over expression of HDAC1 in HepG2 cells leads to significantly reduced amounts of nuclear STAT3 after IL-6 induction, whereas silencing of
HDAC1 resulted in accumulation of total and acetylated
STAT3 in the nucleus
Sun et al., J Immunol 2009
:
In this study we report that
HDAC inhibition acetylates and
activates STAT-3 , which regulates DCs by promoting the transcription of IDO
Pang et al., J Cell Biochem 2011
:
Collectively, our results reveal an important
role of
HDAC1 and HDAC2 in regulating proliferation of renal interstitial fibroblasts, expression of cell cycle proteins and activation of
STAT3