Gene interactions and pathways from curated databases and text-mining

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BMP7 — NCOA3

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Ryoo et al., Gene 2006 : The establishment of an in vitro model system has enabled the investigation of intracellular events including BMP receptor activation, BMP-2 induced R-Smad activation , and kinase activation, and the role of osteogenic transcription factors, such as Runx2, Osx, Dlx5, and Msx2
Elshaier et al., Arthritis Rheum 2009 (MAP Kinase Signaling System) : IL-1beta reduced the number of activin receptor-like kinase 2 (ALK-2) and ALK-3 receptors, inhibited expression of Smad1 and Smad6, delayed and prematurely terminated the onset of OP-1 mediated R-Smad phosphorylation, and affected nuclear translocation of R-Smad/Smad4 complexes
Yamashita et al., J Cell Biol 1995 : Osteogenic protein-1 ( OP-1, also known as bone morphogenetic protein-7 or BMP-7 ), a member of the TGF-beta superfamily which belongs to the BMP subfamily, was found to bind activin receptor type I (ActR-I), and BMP receptors type IA ( BMPR-IA ) and type IB ( BMPR-IB ) in the presence of activin receptors type II (ActR-II) and type IIB ( ActR-IIB )