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PTGS2 — RB1
Text-mined interactions from Literome
Naruse et al., Carcinogenesis 2006
(Bone Neoplasms...) :
Meloxicam, may have both
COX-2 dependent and independent inhibitory actions on
osteosarcoma
Park et al., Planta Med 2006
:
Inhibitory
effects of
ginsenoside-Rb1 on activation of the 12-O-tetradecanoylphorbol 13-acetate induced
cyclooxygenase-2 promoter ... We studied the inhibitory
effects of
ginsenoside-Rb1 ( 1 ) on 12-O-tetradecanoylphorbol 13-acetate ( TPA ) -induced transcriptional activation of the
cyclooxygenase-2 (COX-2) promoter ...
Ginsenoside-Rb1 at 100 microM
inhibited TPA induced transcriptional activation of the
COX-2 promoter ... In conclusion,
ginsenoside-Rb1 inhibits TPA induced
COX-2 promoter activity through the nuclear factor interleukin-6 binding site and not through the nuclear factor-kappaB or cAMP-responsive elements
Xu et al., Cancer Res 2006
(Bone Neoplasms...) :
To investigate a potential
role of
COX-2 in
osteosarcoma , we overexpressed COX-2 in human osteosarcoma cells
Li et al., Neurochem Res 2008
(Hypoxia, Brain) :
Overexpression of
COX-2 did not
increase expression of cyclin D1 or
phosphoretinoblastoma protein (pRb) , or cleavage of caspase 3 suggesting that this cell cycle mechanism does not mediate COX-2 toxicity in this model
Zhao et al., J Exp Clin Cancer Res 2011
(Bone Neoplasms...) :
We examined the
role of
COX-2 in
osteosarcoma