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HMOX1 — PTGS2
Text-mined interactions from Literome
Matsuoka et al., J Cereb Blood Flow Metab 1999
(Ischemic Attack, Transient) :
These results suggest the following : ( 1 ) c-Jun phosphorylation was associated with ischemia/reperfusion induced neuronal apoptosis ; ( 2 )
HO-1 and COX-2 were
induced in CA1 pyramidal neurons, which undergo cell death ; and ( 3 ) most CA1 pyramidal neurons expressed HO-1,
COX-2 , or both, which strongly suggests that these are candidates for neuron killers
Ejima et al., Antioxid Redox Signal 2004
(Endotoxemia) :
The present article reviews our recent studies involving the role of cyclooxygenase
(COX)-2 in host responses to bacterial endotoxemia and its
role in the regulation of nitric oxide synthase (NOS)2 and
heme oxygenase (HO)-1
Krönke et al., Arterioscler Thromb Vasc Biol 2007
:
Moreover, inhibition of
HO-1 enzymatic activity reversed PPAR ligand
mediated inhibition of cell proliferation and expression of
cyclooxygenase-2 in vascular smooth muscle cells
Park et al., Neuropharmacology 2007
(Anoxia) :
Taken together, we conclude that therapeutic use of NS-398 in the treatment of oxidative stress oriented neuronal disorders would be beneficial through dual actions :
HO-1 induction and
COX-2 inhibition
Tsoyi et al., Cell Signal 2008
:
Additionally, silencing
HO-1 by siRNA
prevented CKD712 from inhibiting iNOS expression but not
COX-2
Choi et al., Biochem Biophys Res Commun 2008
:
Furthermore, SnPPIX, a HO-1 inhibitor, reversed the effects of NS-398 on PGE ( 2 ) production, suggesting that
COX-2 activity can be
affected by
HO-1
Sue et al., Nephrol Dial Transplant 2009
(Disease Models, Animal...) :
We evaluated the protective
effects of
HO-1 on several apoptotic parameters induced by gentamicin : cleaved caspases-3 and -9,
cycloxygenase-2 (Cox-2) and subcellular localization of nuclear factor kappa B-p65 ( NF-kappaB-p65 ), Bcl-xl and HS-1 associated protein ( Hax-1 ) in NRK-52E cells
Park et al., Biochem Biophys Res Commun 2008
(Brain Infarction) :
The obligatory
role of
COX-2 expression for induction of
HO-1 in ischemic preconditioned rat brain
Saw et al., Biochem Pharmacol 2010
(Inflammation) :
The combinations were also found to suppress iNOS,
COX-2 , 5-lipoxygenase (5-LOX) and cPLA(2) but
induce HO-1
Pi et al., J Periodontal Res 2010
:
Heme oxygenase-1 mediates nicotine- and lipopolysaccharide induced expression of
cyclooxygenase-2 and inducible nitric oxide synthase in human periodontal ligament cells
Park et al., Neurochem Int 2012
:
We next demonstrated that ar-turmerone induced HO-1 and Nrf-2 activation suppressed the activation of neuroinflammatory molecules in LPS induced microglial cells, and that down-regulation of
HO-1 signals was
sufficient to induce the expression of iNOS,
COX-2 and ROS production in microglial cells
Cheng et al., J Sci Food Agric 2013
(Inflammation) :
A specific inhibitor of
HO-1 , zinc ( II ) protoporphyrin IX,
inhibited the suppression of iNOS and
COX-2 expression by PV
Lee et al., Allergy, asthma & immunology research 2013
:
In addition,
HO-1 induction by the HO activator copper protoporphyrin
suppressed LPS induced
COX-2 expression, which was restored by the addition of exogenous PGE2