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EGFR — SH3KBP1

Pathways - manually collected, often from reviews:

• BioCarta cbl mediated ligand-induced downregulation of egf receptors pathway: EGF R/SRC/EGF complex (EGFR-SRC-EGF) → SH3BP1 (SH3KBP1) (protein ubiquitination, collaborate)
• KEGG Endocytosis: SH3KBP1 → CSF1R/EGFR/ERBB3/ERBB4/FGFR2/FGFR3/FGFR4/FLT1/IGF1R/KDR/KIT/MET/NTRK1/PDGFRA/RET (protein-protein, binding/association)
  
• Reactome Reaction: EGFR → SH3KBP1 (direct_complex)
• Reactome Reaction: EGFR → SH3KBP1 (reaction) Soubeyran et al., Nature 2002, Klapisz et al., J Biol Chem 2002, Haglund et al., Proc Natl Acad Sci U S A 2002, Sigismund et al., Proc Natl Acad Sci U S A 2005, Schmidt et al., Oncogene 2006
• Reactome Reaction: EGFR → SH3KBP1 (indirect_complex) Rosenthal et al., J Biol Chem 1999, Soubeyran et al., Nature 2002, Klapisz et al., J Biol Chem 2002, Haglund et al., Proc Natl Acad Sci U S A 2002, Sigismund et al., Proc Natl Acad Sci U S A 2005, Haglund et al., EMBO Rep 2005

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: EGFR — SH3KBP1 (physical association, affinity chromatography technology) Schmidt et al., Proc Natl Acad Sci U S A 2003*
• IRef Biogrid Interaction: EGFR — SH3KBP1 (physical association, affinity chromatography technology) Yang et al., Cancer Res 2006
• IRef Biogrid Interaction: EGFR — SH3KBP1 (physical association, affinity chromatography technology) Schmidt et al., J Cell Sci 2003
• IRef Biogrid Interaction: EGFR — SH3KBP1 (physical association, affinity chromatography technology) Rønning et al., Exp Cell Res 2011*
• IRef Biogrid Interaction: EGFR — SH3KBP1 (physical association, affinity chromatography technology) Schmidt et al., Mol Cell Biol 2004*
• IRef Biogrid Interaction: EGFR — SH3KBP1 (physical association, affinity chromatography technology) Szymkiewicz et al., J Biol Chem 2002
• IRef Biogrid Interaction: EGFR — SH3KBP1 (physical association, affinity chromatography technology) Soubeyran et al., Nature 2002
• MIPS CORUM Multiprotein complex (monoubiquitination): Multiprotein complex (monoubiquitination) complex (CBLB-EGFR-SH3KBP1) Haglund et al., Proc Natl Acad Sci U S A 2002
• MIPS CORUM CIN85-CBL-SH3GL2-EGFR complex, EGF stimulated: CIN85-CBL-SH3GL2-EGFR complex, EGF stimulated complex (CBL-EGFR-SH3KBP1) Soubeyran et al., Nature 2002
• MIPS CORUM SH3KBP1-CBLB-EGFR complex: SH3KBP1-CBLB-EGFR complex complex (CBLB-EGFR-SH3KBP1) Szymkiewicz et al., J Biol Chem 2002
• IRef Corum Interaction: Complex of CBL-EGFR-SH3KBP1 (association, coimmunoprecipitation) Soubeyran et al., Nature 2002
• IRef Corum Interaction: Complex of EGFR-CBLB-UBB-SH3KBP1 (association, coimmunoprecipitation) Haglund et al., Proc Natl Acad Sci U S A 2002
• IRef Hprd Interaction: Complex of 17 proteins (in vivo) Soubeyran et al., Nature 2002, Szymkiewicz et al., J Biol Chem 2002
• IRef Hprd Interaction: Complex of 13 proteins (in vivo) Haglund et al., Proc Natl Acad Sci U S A 2002
• IRef Intact Interaction: SH3KBP1 — EGFR (physical association, anti bait coimmunoprecipitation) Soubeyran et al., Nature 2002
• IRef Intact Interaction: Complex of SH3KBP1-CBL-SH3GL2-EGFR (association, anti bait coimmunoprecipitation) Soubeyran et al., Nature 2002
• IRef Intact Interaction: Complex of EGFR-CBLB-SH3KBP1-CBLB-SH3KBP1-EGFR (association, anti bait coimmunoprecipitation) Szymkiewicz et al., J Biol Chem 2002
• MIPS Negatome - no physical interaction between proteins Interaction: EGFR — SH3KBP1 (Absence of interaction, coimmunoprecipitation) Haglund et al., Proc Natl Acad Sci U S A 2002

Text-mined interactions from Literome

Wakasaki et al., Neoplasia (New York, N.Y.) 2010 (Carcinoma, Squamous Cell...) : Little is known, however, about a role of CIN85 in EGFR signaling as well as its relevance to tumor development and progression of HNSCC
Schroeder et al., Mol Biol Cell 2012 : In this study we show that EGFR activation leads to a pronounced src mediated tyrosine phosphorylation of CIN85 that subsequently influences EGFR ubiquitination