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CTNND1 — EGFR

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: CTNND1 → EGFR (increases, CTNND1 Activity)
  Evidence: This is taken from supplemental table 2 from PMID 15951569 Cut-offs were 2.25 for increase and 0.5 for decrease LLID were found by converting from GI assession numbers in DAVID Spreadsheet is saved in the project folder for Cell Signaling Project # bduckworth
• KEGG Adherens junction: EGFR/ERBB2 → CTNND1 (protein-protein, inhibition)
• NCI Pathway Database Posttranslational regulation of adherens junction stability and dissassembly: EGFR/EGFR/EGF/EGF complex (EGFR-EGF) → E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin complex (CDH1-CTNNB1-CTNNA1-CTNND1) (modification, activates)
  Miravet et al., Mol Cell Biol 2003, Hoschuetzky et al., J Cell Biol 1994, Shibamoto et al., Cell adhesion and communication 1994
  Evidence: assay, physical interaction
• NCI Pathway Database Stabilization and expansion of the E-cadherin adherens junction: EGFR (EGFR) → E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin complex (CDH1-CTNNB1-CTNNA1-CTNND1) (modification, collaborate)
  Qian et al., EMBO J 2004, Hoschuetzky et al., J Cell Biol 1994, Takahashi et al., Exp Cell Res 1996
  Evidence: assay, physical interaction
• NCI Pathway Database Stabilization and expansion of the E-cadherin adherens junction: E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin complex (CDH1-CTNNB1-CTNNA1-CTNND1) → EGFR/EGFR/EGF/EGF complex (EGFR-EGF) (modification, inhibits)
  Qian et al., EMBO J 2004, Hoschuetzky et al., J Cell Biol 1994, Takahashi et al., Exp Cell Res 1996
  Evidence: assay, physical interaction
• NCI Pathway Database E-cadherin signaling in keratinocytes: EGFR (EGFR) → E-cadherin/Ca2+/beta catenin-gamma catenin/alpha catenin/p120 catenin complex (CDH1-CTNNB1_JUP-CTNNA1-CTNND1) (modification, collaborate)
  Pece et al., J Biol Chem 2000, Betson et al., J Biol Chem 2002
  Evidence: assay, physical interaction
• NCI Pathway Database E-cadherin signaling in keratinocytes: E-cadherin/Ca2+/beta catenin-gamma catenin/alpha catenin/p120 catenin complex (CDH1-CTNNB1_JUP-CTNNA1-CTNND1) → EGFR(dimer) complex (EGFR) (modification, activates)
  Pece et al., J Biol Chem 2000, Betson et al., J Biol Chem 2002
  Evidence: assay, physical interaction

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: EGFR — CTNND1 (direct interaction, pull down) Hazan et al., J Biol Chem 1998
• IRef Hprd Interaction: CTNND1 — EGFR (in vitro) Mariner et al., J Cell Sci 2004*
• IRef Hprd Interaction: CTNND1 — EGFR (in vivo) Mariner et al., J Cell Sci 2004*
• IRef Intact Interaction: Complex of 23 proteins (association, anti bait coimmunoprecipitation) Thelemann et al., Mol Cell Proteomics 2005
• IRef Intact Interaction: Complex of 59 proteins (association, tandem affinity purification) Li et al., Molecular systems biology 2013
• IRef Intact Interaction: Complex of 24 proteins (association, tandem affinity purification) Li et al., Molecular systems biology 2013
• IRef Intact Interaction: Complex of 70 proteins (association, anti bait coimmunoprecipitation) Thelemann et al., Mol Cell Proteomics 2005

Text-mined interactions from Literome

Moro et al., J Biol Chem 2002 : Integrin induced epidermal growth factor (EGF) receptor activation requires c-Src and p130Cas and leads to phosphorylation of specific EGF receptor tyrosines
Kang et al., PloS one 2011 : We investigated the molecular mechanism by which p130Cas affects the endocytic regulation of EGFR ... Biochemical quantification revealed that cell adhesion to fibronectin ( FN ) increases total EGFR levels and its phosphorylation, and that p130Cas is required for this process