Avissar et al., J Gastrointest Surg 2009
(Adenocarcinoma...) :
CDX2 mRNA induction was markedly reduced by EGFR blockade with Mab528
Kusaka et al., Scand J Gastroenterol 2012
(Barrett Esophagus...) :
Although previous studies revealed that the expression of caudal-type homeobox 2 (CDX2) , an important marker of BE, might be induced through Epidermal Growth Factor Receptor (EGFR) , the roles of NO in this signal transduction remain unclear ... Specific inhibitors for EGFR, AG1478 and small interfering RNA for EGFR ( EGFR-siRNA ) were employed to elucidate the role of EGFR in the induction of CDX2 ... Both EGFR phosphorylation and CDX2 induction were significantly diminished by AG 1478 and EGFR-siRNA ... We revealed for the first time that extrinsic NO might directly induce CDX2 expression through EGFR phosphorylation