Gene interactions and pathways from curated databases and text-mining

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LEP — SOCS1

Text-mined interactions from Literome

Bjørbaek et al., J Biol Chem 1999 : We here show that in CHO cells stably expressing the long form of the leptin receptor ( CHO-OBRl ), leptin induces transient expression of endogenous SOCS-3 mRNA but not of CIS, SOCS-1 , or SOCS-2 mRNA
Motta et al., Regul Pept 2004 : Furthermore, we show that leptin and PRL are able to effectively enhance SOCS-1 gene expression in the HC11 cell line
Elinav et al., J Hepatol 2006 (Carcinoma, Hepatocellular...) : Leptin induced increased mRNA expression of STAT2 and SOCS1 on HCC cell lines
Jørgensen et al., J Exp Biol 2013 : In an in vitro study with liver slices it was shown that recombinant rainbow trout leptin stimulated SOCS1 and SOCS3 expression, but not SOCS2, IGF-I or genes of enzymes involved in lipid ( G6PDH ) and amino acid ( AspAT ) metabolism