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LEP — MMP13

Text-mined interactions from Literome

Park et al., Exp Mol Med 2001 (Arteriosclerosis...) : Leptin also induced increases of MMP-2, MMP-9 , TIMP-1, and Up-regulated the human coronary artery smooth muscle cells ( HCASMCs )
Quinton et al., Am J Reprod Immunol 2003 : Expression of leptin receptor isoforms in vitro : lack of effects of leptin on endometrial cytokine and MMP production ... The effect of leptin on cell growth and on the production of cytokines [Leukaemia Inhibitory Factor (LIF), interleukin 6 and tumour necrosis factor-alpha ] and matrix metalloproteinases ( MMP ) ( MMP2 and MMP-9 ) was also investigated ... Leptin had no effect on cytokine and MMP production by these cells
Schulz et al., Biol Reprod 2004 : Our results suggest that leptin may play a role in the establishment of the placenta during early pregnancy and that this function is dependent on MMP activity
Simopoulou et al., Osteoarthritis Cartilage 2007 (Obesity...) : Also, leptin had a detrimental effect on chondrocyte proliferation and induced IL-1beta production and MMP-9 and MMP-13 protein expression
Iliopoulos et al., Ann Rheum Dis 2007 (Osteoarthritis) : Epigenetic regulation of leptin affects MMP-13 expression in osteoarthritic chondrocytes : possible molecular target for osteoarthritis therapeutic intervention ... We found a correlation between leptin expression and DNA methylation and also that leptin controls MMP-13 activity in chondrocytes
Schram et al., J Mol Cell Cardiol 2008 : Here we investigated the effects of leptin , circulating levels of which are typically increased in obese individuals, on MMP and collagen expression and MMP activity in isolated cardiac myofibroblasts
Yeh et al., Glia 2009 (Brain Neoplasms...) : Leptin induces migration and invasion of glioma cells through MMP-13 production ... In addition, we found that the expression of matrix metalloproteinase-13 (MMP-13) but not of MMP-2 and MMP-9 was increased in response to leptin stimulation ... The up-regulation of MMP-13 induced by leptin was mainly through p38 MAP kinase and NF-kappaB pathway
Bao et al., Mol Biol Rep 2010 : Leptin significantly increased both gene and protein levels of MMP-2, MMP-9 , cathepsin D, and collagen II, while decreased bFGF markedly in cartilage
Luo et al., Zhong Nan Da Xue Xue Bao Yi Xue Ban 2009 : [ Effect of leptin on inducible NO and MMP-13 in rabbit articular chondrocytes in vitro ] ... Leptin can induce MMP-13 and have synergistic induction effect on NO with TNF-alpha in rabbit articular chondrocytes in vitro
Pallu et al., Arthritis Res Ther 2010 (Obesity...) : Higher leptin levels induced the expression of IGF-1, type 2 collagen, TIMP-2 and MMP-13
Tao et al., Arterioscler Thromb Vasc Biol 2013 (Aortic Aneurysm, Abdominal...) : Leptin and leptin receptor antigen were evident in all AAAs, and leptin, MMP-9 , and MMP-12 mRNA was increased relative to age matched nondilated controls