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NFKBIE — TNF
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Laskov et al., Eur Cytokine Netw 2005
(Burkitt Lymphoma...) :
Our results thus show that in Ramos cells,
TNF-alpha and CD40L have common, as well as differential, signaling
effects on the IkappaBalpha, IkappaBbeta and
IkappaBepsilon , which form inhibitory complex ( es ) with the NF-kappaB cytosolic proteins
Stefansson et al., J Biol Chem 2006
:
Knockdown of PP6 or PP6R1 but not PP6R3 with siRNA significantly enhanced degradation of endogenous
IkappaBepsilon in
response to
tumor necrosis factor-alpha
Stefansson et al., Biochemistry 2008
:
Knockdown of PP6R1 or Ankrd28, but not PP6R3, produced equivalent enhancement of
IkappaBepsilon degradation in
response to
TNFalpha