◀ Back to MMP2

FUT1 — MMP2

Text-mined interactions from Literome

Chen et al., World J Gastroenterol 2001 (Hyperoxia) : In the situation of hypoxia for 12h, the expression of MMP-2 protein was enhanced ( hypoxia group positive indexes : 5.7 +/- 2.0, n=10 ; control : 3.2 +/- 1.0, n = 7 ; P < 0.05 ), while TIMP-2 protein was decreased in HSC ( hypoxia group positive indexes : 2.5 +/- 0.7, n = 10 ; control : 3.6 +/- 1.0, n = 7 ; P < 0.05 ), and the activity ( total A ) of MMP-2 in supernatant declined obviously ( hypoxia group : 7.334 +/- 1.922, n = 9 ; control : 17.277 +/- 7.424, n = 11 ; P < 0.01 )
Galli et al., Hepatology 2005 (Liver Cirrhosis) : In conclusion, our findings suggest that MMP-2 is required for the mitogenic and proinvasive effects of ROS on HSC and demonstrate that ERK1/2 and PI3K are the main signals involved in ROS mediated MMP-2 expression
Han et al., J Gastroenterol Hepatol 2006 (Liver Cirrhosis) : In vitro experiments also demonstrated the role of MMP in activation of HSC cultured in 3-D ECM
Zhang et al., Hepatogastroenterology 2007 (Disease Models, Animal...) : The expression of TGF-beta1, MMP-2 and TIMP-1 increased in liver or in HSC of hepatic fibrosis rats and decreased after treatment with IL-10
Wang et al., Zhongguo Zhong Xi Yi Jie He Za Zhi 2009 (Liver Cirrhosis, Experimental...) : CME could inhibit the initiation of HSC by decreasing MMP-2 and MMP-9 activity in the early stage, and prevent its formation by decreasing SECs injury and phenotypic changes