Mix et al., J Biol Chem 2007
(Inflammation) :
Furthermore, MMP-1 promoter activity is potently suppressed by NURR1 , resulting in a significant reduction in endogenous MMP-1 mRNA and secreted pro-MMP-1 protein
Mix et al., Arthritis Rheum 2012
(Arthritis, Rheumatoid) :
Orphan nuclear receptor NR4A2 induces synoviocyte proliferation, invasion, and matrix metalloproteinase 13 transcription ... MMP-13 gene expression was synergistically induced by NR4A2 and TNFa, while expression of TIMP-2 was antagonized ... NR4A2 directly transactivated the proximal MMP-13 promoter, and a point mutation in the DNA binding domain of NR4A2 abolished transcriptional activation