Nguyen et al., Int J Biochem Cell Biol 2007
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Overexpression of phospholipase C-gamma1 inhibits NGF induced neuronal differentiation by proliferative activity of SH3 domain ... Since the biological role of phospholipase C (PLC) gamma1 in neuronal differentiation still barely understood, here, we report that overexpression of PLC gamma1 inhibits neurite outgrowth and prolonged proliferation ability of PLC gamma1 contribute to the alteration of cell cycle regulatory proteins, subsequently exiting from cell growth arrest
Bae et al., J Neurochem 1998
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To assess the role of PLC-gamma1 in mediating the neuronal differentiation induced by NGF treatment, we established PC12 cells that overexpress whole PLC-gamma ( PLC-gamma1PC12 ), the SH2-SH2-SH3 domain ( PLC-gamma1SH223PC12 ), SH2-SH2 deleted mutants ( PLC-gamma1deltaSH22PC12 ), and SH3 deleted mutants ( PLC-gamma1deltaSH3PC12 )