Yun et al., Biochem Biophys Res Commun 2007
:
Lef1 regulates COX-2 transcription in chondrocytes ... Furthermore, decrease of Lef1 expression using Lef1 siRNA results in the downregulation of COX-2 expression ... Our results indicate a pivotal role of Lef1 in the regulation of COX-2 transcription in arthritic chondrocytes
Stasinopoulos et al., Prostaglandins Other Lipid Mediat 2012
(Breast Neoplasms) :
We also report that COX-2 silenced cells have reduced nuclear accumulation of LEF-1 protein and that the COX-2 product PGE ( 2 ) partially restored nuclear LEF-1 expression in COX-2 silenced cells