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IL3 — IL5

Pathways - manually collected, often from reviews:

• Reactome Reaction: IL3 → IL5 (reaction) Sakamaki et al., EMBO J 1992, Duronio et al., J Biol Chem 1992, Sorensen et al., J Biol Chem 1989, Quelle et al., Mol Cell Biol 1994, Feng et al., Mol Cell Biol 1997, Bone et al., J Biol Chem 1997, Flores-Morales et al., Mol Cell Endocrinol 1998

Text-mined interactions from Literome

Suchin et al., J Am Acad Dermatol 2001 (Eosinophilia...) : Increased interleukin 5 production in eosinophilic Sézary syndrome : regulation by interferon alfa and interleukin 12
Zirngibl et al., Mol Cell Biol 2002 : Bone marrow derived Fps/Fes-null macrophages showed no defects in granulocyte-macrophage colony stimulating factor-, interleukin 6 (IL-6)-, or IL-3 induced activation of signal transducer and activator of transcription 3 ( Stat3 ) and Stat5A or LPS induced degradation of I kappa B or activation of p38, Jnk, Erk, or Akt
Matsuzaki et al., Cancer Sci 2006 : We have demonstrated previously that the Th1-cytokine conditioned bone marrow derived dendritic cell ( BMDC ) subset BMDC1 ( generated in the presence of granulocyte-macrophage colony stimulating factor [GM-CSF ] + interleukin [ IL]-3 + interferon [ IFN]-gamma+ IL-12 ) induces a much stronger type 1 immune response than BMDC0 ( GM-CSF + IL-3 )
Lopez et al., J Cell Physiol 1990 (Leukemia, Myelogenous, Chronic, BCR-ABL Positive) : Human interleukin-3 inhibits the binding of granulocyte-macrophage colony stimulating factor and interleukin-5 to basophils and strongly enhances their functional activity
Ema et al., Blood 1990 : Eosinophil ( Eo ) colonies were only formed by CD34+, CD33- cells in response to IL-3 , but scarcely formed by CD34+ cells in the presence of IL-5
Lopez et al., J Biol Chem 1991 : The binding of IL-5 was rapid at 37 degrees C while requiring several hours to reach equilibrium at 4 degrees C. Specificity studies revealed that the two other human eosinophilopoietic cytokines IL-3 and granulocyte-macrophage colony stimulating factor ( GM-CSF ) inhibited the binding of 125I-IL-5 to eosinophils
Cohen et al., Immunol Lett 1991 : We have studied the production of interleukin-1 (IL-1), interleukin-6 (IL-6) and tumor necrosis factor (TNF) by mouse peritoneal macrophages triggered by lipopolysaccharide (LPS) in the presence or absence of IL-3
Murata et al., Biochem Biophys Res Commun 1990 : T88-M cells were found to proliferate in response to IL-3 as well as IL-5, and the phosphoproteins in T88-M cells could be induced by IL-3 stimulation in a similar manner of those induced by IL-5
Cavaillon et al., Cell Immunol 1990 : Induction of interleukin-3 by interleukin-1 in the absence of other exogenous stimuli
Swain et al., Proc Natl Acad Sci U S A 1981 : We conclude that the C.C3.11.75 TRF activity is not due to interleukin 1 or to interleukin 2 but to a third factor provisionally designated as ( DL ) TRF
Dührsen et al., Blood 1994 (Leukemia, Experimental) : They were not viable in unstimulated cultures, but formed IgM+ lymphoid colonies in response to interleukin-2 (IL-2), IL-4, IL-5 , IL-6, IL-7, and Steel factor, and macrophage colonies in response to IL-3
Kita et al., C R Seances Soc Biol Fil 1994 : Although the expressions of IL-1 beta, IL-4, IL-5 , IL-6, TNF-alpha and IFN-gamma mRNA were detected in all the embryos tested, the expressions of IL-2, IL-3 , IFN-alpha and IFN-beta mRNA were not detected at all
Zaitseva et al., Infect Immun 1995 : Gamma interferon ( IFN-gamma ), interleukin-2 (IL-2), IL-4, and IL-5 induction was assayed by mRNA-specific PCR and by enzyme linked immunosorbent assay and bioassay for protein production
Kita et al., C R Seances Soc Biol Fil 1994 (Stomach Neoplasms) : Although IL-1 beta, IL-4, IL-5 , IL-6, IL-7, IL-8, TNF-alpha, IFN-alpha and IFN-gamma mRNA were detected in all the samples tested, IL-3 and IFN-beta mRNA was not detected at all
Wierenga et al., Blood 1993 (Eosinophilia) : High production of mature eosinophils in liquid cultures of unseparated mononuclear bone marrow cells could only be induced by Th2 SN, which could be more than 90 % blocked by anti-IL-5 , but not by anti-IL-3 or anti-GM-CSF
Bressler et al., J Allergy Clin Immunol 1997 : IL-5, IL-3 , and GM-CSF messenger RNA increased within 2 hours of mast cell activation, with IL-5 and GM-CSF message remaining elevated for 24 hours, whereas IL-3 mRNA rapidly declined