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ENPP3 — IL3

Text-mined interactions from Literome

Majlesi et al., J Leukoc Biol 2003 : Cerivastatin and atorvastatin inhibit IL-3 dependent differentiation and IgE mediated histamine release in human basophils and downmodulate expression of the basophil-activation antigen CD203c/E-NPP3
Hauswirth et al., Int J Immunopathol Pharmacol 2007 (Rhinitis, Allergic, Seasonal) : The IL-3 induced upregulation of CD203c was also observed in highly enriched basophils and was counteracted by a blocking antibody against the alpha chain of the IL-3 receptor ( CD123 ) ... The IL-3 induced upregulation of CD203c was also found to depend on the presence of calcium ... To analyze signaling pathways involved in IL-3 induced upregulation of CD203c , pharmacologic inhibitors were applied ... The PI3-kinase inhibitors, wortmannin and LY294002 counteracted the IL-3 induced expression of CD203c , whereas MEK- and PKC inhibitors showed no effects ... In conclusion, IL-3 upregulates expression of CD203c on basophils through a specific receptor and via a PI3-kinase dependent signaling-pathway ... Compared to FcepsilonRI mediated cell activation, IL-3 induced upregulation of CD203c is a late ( r ) event and is not accompanied by upregulation of CD63