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KDM1A — TP53

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: KDM1A — TP53 (physical association, affinity chromatography technology) Tsai et al., Mol Cell Biol 2008*
• IRef Biogrid Interaction: KDM1A — TP53 (direct interaction, pull down) Tsai et al., Mol Cell Biol 2008*
• IRef Biogrid Interaction: KDM1A — TP53 (direct interaction, enzymatic study) Huang et al., Nature 2007*
• IRef Biogrid Interaction: KDM1A — TP53 (direct interaction, pull down) Huang et al., Nature 2007*
• IRef Biogrid Interaction: KDM1A — TP53 (physical association, affinity chromatography technology) Huang et al., Nature 2007*
• IRef Intact Interaction: Complex of 29 proteins (association, anti tag coimmunoprecipitation) Coffill et al., EMBO Rep 2012

Text-mined interactions from Literome

Huang et al., Nature 2007 : p53 is regulated by the lysine demethylase LSD1
Sareddy et al., Oncotarget 2013 (Brain Neoplasms...) : Inhibition of KDM1 promoted up regulation of the p53 target genes p21 and PUMA ... Inhibition of KDM1 increased levels of H3K4-me2 and H3K9-Ac histone modifications, reduced H3K9-me2 modification and promoted expression of p53 target genes ( p21 and PUMA ), leading to apoptosis of glioma xenograft tumors