Gene interactions and pathways from curated databases and text-mining

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MARCKS — PRKCD

Pathways - manually collected, often from reviews:

  • OpenBEL Selventa BEL large corpus: MARCKS → PRKCD (increases, MARCKS Activity)
    Evidence: MARCKS phosphorylation was inhibited by PKC-delta siRNA, ROKalpha siRNA, and C3 toxin (a Rho protein inhibitor), suggesting that the PKC-delta and the Rho/ROK pathways are necessary for MARCKS activation.
  • KEGG Fc gamma R-mediated phagocytosis: PRKCD/PRKCE → MARCKS/MARCKSL1 (protein-protein, inhibition)