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IL13 — RHOA
Text-mined interactions from Literome
Chiba et al., Am J Respir Cell Mol Biol 2009
(Asthma...) :
To elucidate the role of IL-13 on the induction of BSM hyperresponsiveness,
effects of
IL-13 on contractility and
RhoA expression in BSMs were investigated ... In cultured human BSM cells,
IL-13 caused an up-regulation of
RhoA ... The
IL-13 induced up-regulation of
RhoA was inhibited by leflunomide, an inhibitor of signal transducer and activator of transcription 6 ( STAT6 )
Goto et al., Pharmacol Res 2010
:
Luciferase based assay showed that the
RhoA promoter activity was
augmented by both
IL-13 and TNF-alpha
Goto et al., Biol Pharm Bull 2010
(Asthma...) :
The upregulation of
RhoA induced by
interleukin (IL)-13 and tumor necrosis factor (TNF)-alpha, major mediators for development of AHR, was observed in hBSMCs ... Prednisolone partly inhibited the
IL-13 induced
RhoA upregulation and RhoA promoter activity, although prednisolone had no effects on the activations of signal transducers and activators of transcription ( STAT ) 6 and nuclear factor (NF)-kappaB ... These findings suggest that prednisolone might inhibit NF-kappaB induced transcription via interaction between glucocorticoid receptor ( GR ), resulting in an inhibition of
RhoA upregulation
induced by
IL-13 and TNF-alpha
Kudo et al., Proc Natl Acad Sci U S A 2013
(Asthma...) :
Mfge8 inhibited
IL-13 induced NF-?B activation and induction of
RhoA