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PTMA — TP53

Text-mined interactions from Literome

Kobayashi et al., Cancer Res 2006 : Here, we show that inappropriate activity of prothymosin alpha (PTMA) , an oncoprotein overexpressed in human cancers, triggers a p53 response ... PTMA , known to interact with HATs, led to increased levels of acetylated p53 ... PTMA did not increase the transcriptional activity of an acetylation-deficient p53 mutant, suggesting that p53 acetylation is an indispensable part of the p53 response to PTMA ... Chromatin immunoprecipitation assays showed that excess PTMA associates with the p21 promoter and results in increased levels of acetylated p53 at the p21 promoter
Zakharova et al., Mol Biol (Mosk) 2008 : Ectopic expression of prothymosin alpha enhanced not only p53 dependent transcription, but also intracellular level of p53 in HeLa ( but not HCT116 ) cells