Caraglia et al., Frontiers in bioscience : a journal and virtual library 2005
:
Interestingly, we have found that DTX reduces the expression of mutated p53 in HT-29 and increases the expression of wild type in KB and HCC1937 cells ... Moreover, DTX reduces ubiquitination of the wild type p53 in KB and HCC1937 cells and increases the ubiquitin conjugated form of mutated p53 in HT-29 cells
Vaskivuo et al., Toxicol Appl Pharmacol 2006
(Ovarian Neoplasms) :
In this study, we show that AZT, cisplatin ( CDDP ) and docetaxel ( DTX ) all induce unique molecular responses in OVCAR-3 ovarian carcinoma cells carrying a mutated p53, while in A2780, ovarian carcinoma and MCF-7 breast carcinoma cells with wild type p53, all of these drugs cause similar p53 responses