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IL6 — TIMP1
Text-mined interactions from Literome
Kossakowska et al., Blood 1999
(Lymphoma, Non-Hodgkin...) :
Moreover, in human lymphoid cell lines of B- and T-cell origin ( Raji, Jurkat, and NC-37 ),
IL-6 stimulated production of MMP-9 and MMP-2 but not
TIMP-1
Seitz et al., Rheumatology (Oxford) 2000
(Arthritis, Rheumatoid) :
Moreover, PBMNC of healthy donors revealed that MTX also stimulated TIMP-1 and IL-6 release in vitro,
IL-6 being partially
responsible for the induction of
TIMP-1 production
Irwin et al., J Periodontol 2002
(Periodontal Diseases) :
IL-6 and sIL-6r, either alone or in combination,
had no marked effect on
TIMP expression or cell growth
Sanchez et al., Biochem Pharmacol 2003
:
IL-1beta increased
IL-6 , IL-8, MIP-1beta, NO, PGE ( 2 ) and MMP-3 productions, but
inhibited AGG and
TIMP-1 synthesis
Dasu et al., Burns Incl Therm Inj 2003
:
MMP-1 and
TIMP-1 mRNA expression were markedly
increased with
IL-6 and TNF-alpha treatment and remains unchanged with IL-1beta
Kordula et al., FEBS Lett 1992
(Carcinoma, Hepatocellular...) :
We show at mRNA and protein levels that
TIMP-1 is expressed in differentiated human hepatoma cells ( HepG2 ) and that its synthesis is
up-regulated by
interleukin-6 (IL-6) , transforming growth factor beta 1 and phorbol 12-myristate 13-acetate
Kralisch et al., FEBS Lett 2005
:
Interestingly, TNFalpha and
IL-6 induced
TIMP-1 protein secretion more than 3- and 2-fold, respectively ... Moreover, the thiazolidinedione troglitazone partly reversed TNFalpha- but not
IL-6 induced
TIMP-1 synthesis
Nieto et al., Hepatology 2006
:
MMP13, a protease that degrades extracellular collagen I, decreased in the cocultures, while
TIMP1 , a MMP13 inhibitor, increased ; and these effects were
prevented by catalase,
anti-IL-6 , and siRNA-IL-6
Guo et al., Braz J Med Biol Res 2007
(Carcinoma, Hepatocellular...) :
Further studies indicated that
TIMP-1 mediated the inhibitory effect of
IL-6 on BEL-7402 cell proliferation in a STAT3 dependent manner, which could further accelerate the expression of the cyclin dependent kinase inhibitor p21 ... A dominant negative STAT3 mutant totally abolished
IL-6 induced
TIMP-1 expression and its biological functions
Lotz et al., J Biol Chem 1991
:
Interleukin-6 induces the synthesis of
tissue inhibitor of metalloproteinases-1/erythroid potentiating activity ( TIMP-1/EPA )
Sato et al., Biochem Biophys Res Commun 1990
:
IL-6 did not modulate the expression of MMPs by these fibroblasts, but the production of
TIMP was
enhanced by IL-6 in a dose dependent manner, whereas IL-1 stimulated the production of both MMPs and TIMP
Pini et al., J Leukoc Biol 2012
(Inflammation...) :
In DIO mice, production of OPN and
TIMP-1 was increased for a prolonged period, and this was
mediated by
IL-6 in the liver but not the pancreas
Roeb et al., FEBS Lett 1994
(Acute-Phase Reaction) :
TIMP-1 protein expression is
stimulated by IL-1 beta and
IL-6 in primary rat hepatocytes ... In primary rat hepatocytes we show for the first time that
TIMP-1 protein expression is up-regulated upon
stimulation with IL-1 beta and
IL-6
Günther et al., Arthritis Rheum 1994
:
To investigate the
role of
interleukin-6 (IL-6) and transforming growth factor beta 1 ( TGF beta 1 ) in the regulation of
tissue inhibitor of metalloproteinases-1 ( TIMP-1 ) synthesis in human articular chondrocytes ... In contrast to the findings in a previous study,
IL-6 did not
stimulate TIMP-1 expression in these cells, whereas TGF beta 1 was an important inducer of TIMP-1 mRNA and protein synthesis
Shingu et al., Clin Exp Immunol 1993
:
In addition, tumour necrosis factor-alpha (TNF-alpha) significantly inhibited and
IL-6 significantly
enhanced TIMP production in endothelial cells, synovial cells and chondrocytes
Gatsios et al., Eur J Biochem 1996
:
Interleukin-6 itself had no effect on synovial lining cells but a complex of interleukin-6 and the soluble interleukin-6 receptor induced activation of signal transducer and activator of transcription ( STAT ) factors in these cells and
regulated TIMP-1 and TIMP-3 expression in a similar fashion as oncostatin M
Franchimont et al., J Biol Chem 1997
:
IL-6 and IL-6sR
enhanced the expression of
tissue inhibitor of metalloproteinases 1
Alexander et al., Curr Eye Res 1998
:
A phorbol mitogen ( TPA ), and TNF alpha and beta,
interleukin-1 alpha and PDGF BB
stimulate gelatinase B, stromelysin, interstitial collagenase and
TIMP-1 expression, while having negligible effects on gelatinase A expression ; TIMP-2 levels are reduced by TNF but not affected by the other treatments
Silacci et al., J Biol Chem 1998
:
TIMP-1 production by isolated human articular synovial fibroblasts and chondrocytes, stimulated by IL-6 and/or its soluble receptor, was first assayed by specific enzyme linked immunosorbent assay ; the slight stimulatory
effect of
IL-6 on
TIMP-1 production by both types of cells was markedly amplified by the addition of soluble receptor, the maximal secretion being observed only at 96 h. TIMP-1 mRNA expression, determined by ribonuclease protection assay, was induced by IL-6 together with its soluble receptor, but TIMP-2 and -3 mRNAs were not affected by these factors