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HSP90AB1 — IL6
Text-mined interactions from Literome
Ripley et al., Immunology 1999
:
Recent studies have shown that the cytokine
IL-6 activates
hsp 90 gene expression via specific transcription factors that include STAT-3 ( signal transducer and activator of transcription 3 )
Ripley et al., J Autoimmun 2001
(Lupus Erythematosus, Systemic) :
These results support a model in which elevated levels of
IL-6 in SLE patients
induce elevated levels of
hsp90 protein which in turn results in the production of autoantibodies to this protein
Stephanou et al., Biochem J 1997
:
Hence the
induction of
hsp90 protein accumulation by
IL-6 is likely to be dependent on the enhanced activity of the hsp90 beta gene promoter produced by increased levels of NF-IL-6 and/or NF-IL-6 beta
Stephanou et al., Biochem J 1998
:
The nuclear factor interleukin-6 ( NF-IL6 ) and signal transducer and activator of transcription-3 ( STAT-3 ) signalling pathways co-operate to mediate the
activation of the
hsp90beta gene by
interleukin-6 but have opposite effects on its inducibility by heat shock ... The levels of the 90 kDa heat-shock protein ( hsp90 ) and the activity of the
hsp90beta gene promoter are
increased in response to treatment by
interleukin (IL)-6