Gene interactions and pathways from curated databases and text-mining

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MNAT1 — PCNA

Text-mined interactions from Literome

Lee et al., Curr Biol 1999 : Cdc2-cyclin complexes isolated from the arrested cells could be activated in vitro by recombinant CAK , whereas complexes from wild-type cells or either of the single mutants were refractory to activation
Rank et al., Biochem Biophys Res Commun 2000 : A synthetic peptide, ACRRLFGPVDSE, from the N-terminal residues 17-28 of p21, was also a potent inhibitor of CAK mediated cdk2/cyclin E phosphorylation
Kim et al., J Biol Chem 2001 : For example, CDK9 was not phosphorylated by CAK, whereas CDK2-cyclin A kinase activity was dramatically enhanced by CAK
Brabazon et al., Biochim Biophys Acta 2002 : Cyclin dependent kinase 8 (cdk8) regulates transcription by phosphorylating RNA polymerase II and TFIIH
Kwon et al., Gene 1996 : p27Kip1 directly inhibits the catalytic activity of cyclin/cdks ( cyclin dependent kinase ) complexes and/or interferes physically with cyclin/cdks activation by CAK