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FGF2 — NAMPT

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Bae et al., Cardiovasc Res 2011 : Notch1 mediates visfatin induced FGF-2 up-regulation and endothelial angiogenesis ... Visfatin also stimulated fibroblast growth factor-2 (FGF-2) gene expression in a Notch1 dependent manner ... Enforced expression of active Notch1 intracellular domain increased FGF-2 protein levels and stimulated endothelial tube formation, whereas blocking Notch1 signalling or knockdown of Notch1 by small interfering RNA suppressed visfatin induced FGF-2 up-regulation and angiogenesis ... Our data provide the first example of Notch1 dependent endothelial FGF-2 induction by visfatin and of Notch1 activation in visfatin stimulated endothelial angiogenesis, suggesting that the signalling axis of visfatin/Notch1/angiogenic factors like FGF-2 might be a valuable target for pathological angiogenesis
Yuan et al., Sichuan Da Xue Xue Bao Yi Xue Ban 2010 : [ Effect of visfatin on the expression of basic fibroblast growth factor in rat hepatic stellate cells ] ... To investigate the effect of visfatin on the expression of basic fibroblast growth factor ( FGF-2 ) in rat hepatic stellate cells ( HSCs ) ... Visfatin could induce FGF-2 mRNA expression in rat HSCs in a dose- and time dependent manner