Schecter et al., J Leukoc Biol 2004
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MCP-1 induces a time- and concentration dependent phosphorylation of the mitogen activated protein kinases p42/44 Hirata Terra et al., Anal Biochem 2004
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Here, we describe an alternative bioassay based on MCP-1 induced phosphorylation of the mitogen activated protein kinases ( MAPK ) p44 ( ERK1 ) and p42 ( ERK2 )
Fasshauer et al., Biochem Biophys Res Commun 2004
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Studies using pharmacological inhibitors suggested that the positive effects of GH and IL-6 on MCP-1 synthesis are at least in part mediated by janus kinase 2 and p44/42 mitogen activated protein kinase
Sommer et al., Obesity (Silver Spring) 2010
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Signaling studies suggested that p44/42 mitogen activated protein (MAP) kinase is involved in visfatin induced MCP-1 mRNA expression in hMSC-Ads
Fang et al., J Biol Chem 2012
(Breast Neoplasms...) :
RNA interference of CCR2 expression in breast cancer cells significantly inhibited CCL2 induced migration, survival, and phosphorylation of Smad3 and p42/44MAPK proteins ... These data indicate that Smad3 signaling through MEK-p42/44MAPK regulates CCL2 induced cell motility and survival, whereas CCL2 induction of MEK-p42/44MAPK signaling independent of Smad3 functions as an alternative mechanism for cell survival