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CXCR4 — PRKAR2A
Text-mined interactions from Literome
Masci et al., J Leukoc Biol 2003
:
Of note, the ligation of
CXCR4 by stromal cell derived factor-1alpha but not the engagement of CD4 by monoclonal antibody
stimulates the
PKA activity and induces a long lasting hyporesponsivity state in naive CD4+ lymphocytes
Hajishengallis et al., Proc Natl Acad Sci U S A 2008
(Bacteroidaceae Infections) :
This is accomplished through its surface fimbriae, which induce CXCR4/TLR2 co-association in lipid rafts and interact with both receptors : Binding to
CXCR4 induces cAMP dependent
protein kinase A (PKA) signaling, which in turn inhibits TLR2 mediated proinflammatory and antimicrobial responses to the pathogen
Stückemann et al., Development 2012
:
We show that
Cxcr4a inhibits
PKA activity independently of Hh signalling, and propose that Cxcr4a enhances Hh-dependent proliferation by promoting the activity of Gli1