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CASP8 — HTT
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Li et al., Hum Mol Genet 2000
(Huntington Disease) :
Intranuclear
huntingtin increases the expression of
caspase-1 and induces apoptosis ... Here we report that intranuclear
huntingtin induces the activation of
caspase-3 and the release of cytochrome c from mitochondria in cultured cells ... We show that intranuclear
huntingtin increases the expression of
caspase-1 , which may in turn activate caspase-3 and trigger apoptosis ... We propose that the increased level of
caspase-1 induced by intranuclear
huntingtin contributes to HD-associated cell death
Zhang et al., EMBO J 2006
(Nerve Degeneration) :
Huntingtin inhibits
caspase-3 activation ... Huntingtin depletion resulted in caspase-3 activation, and overexpression of
huntingtin resulted in
caspase-3 inhibition ... Although reduction of
huntingtin levels
resulted in
caspase-3 activation in all conditions examined, the cellular response was cell-type specific ... These data demonstrate that
huntingtin inhibits
caspase-3 activity, suggesting a mechanism whereby caspase mediated huntingtin depletion results in a detrimental amplification cascade leading to further caspase-3 activation, resulting in cell dysfunction and cell death
Leyva et al., Chem Biol 2010
(Disease Models, Animal...) :
In this study, the identified nonpeptidic caspase inhibitors were used to confirm the role of
caspase mediated
Htt proteolysis in HD
Khoshnan et al., Neurobiol Dis 2011
(Disease Progression...) :
Activation of IKKß by DNA damage triggers
caspase dependent cleavage of WT and mutant
Htt and enhances the accumulation of oligomeric fragments
Bodai et al., Bioessays 2012
(Huntington Disease...) :
In
response to mutant
Htt , ERK is activated and directs a protective transcriptional response and inhibits
caspase activation