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IRS2 — STAT6

Pathways - manually collected, often from reviews:

• NCI Pathway Database IL4-mediated signaling events: IL4/IL4R/JAK1/IL2R gamma/JAK3/FES/IRS2 complex (IL4-IL4R-JAK1-IL2RG-JAK3-FES-IRS2) → STAT6 (dimer) complex (STAT6) (T-helper 2 cell differentiation, activates)
  Wurster et al., Mol Cell Biol 2002, Swain et al., J Immunol 1990, Shimoda et al., Nature 1996, Kaplan et al., Immunity 1996, Dent et al., Science 1997, Dent et al., Proc Natl Acad Sci U S A 1998
  Evidence: mutant phenotype, other species

Text-mined interactions from Literome

Inoue et al., J Biochem 2007 : Tyrosine phosphorylation, and thereby the activation of Stat6 and IRS-2, is critical for IL-4 signalling ; however, only the activation of Stat6 , not the IRS-2 dependent phosphorylation of Akt, was perturbed in Dok-1-deficient cells stimulated with IL-4
White et al., Am J Physiol Lung Cell Mol Physiol 2009 : This reparative response does not require STAT6 activation, but rather requires IRS-1 and/or IRS-2