◀ Back to EPHB2

EPHB2 — P2RX1

Text-mined interactions from Literome

Li et al., Zhonghua Yi Xue Za Zhi 2001 (Neoplasm Metastasis...) : To investigate the mechanism of the activation of signal transduction of ERK induced by purinergic receptor agonist ATP in prostate cancer cells with different metastatic potential
Oury et al., Blood 2002 (MAP Kinase Signaling System) : Because ATP released from the dense granules during platelet activation contributes to platelet aggregation elicited by low doses of collagen, and because collagen causes ERK2 phosphorylation, we have investigated the role of P2X(1) mediated ERK2 activation in these platelet responses
Toth-Zsamboki et al., J Biol Chem 2003 : P2X1 mediated ERK2 activation amplifies the collagen induced platelet secretion by enhancing myosin light chain kinase activation ... The secreted ATP mediated P2X1 dependent ERK2 activation induced by low collagen concentrations contributes to MLC kinase activation since P2X1 desensitization or blockade of ERK2 phosphorylation by U0126 strongly attenuated MLC phosphorylation, degranulation, and aggregation
Oury et al., Journal of thrombosis and haemostasis : JTH 2006 (Thrombosis...) : In conclusion, P2X(1) and ERK2 both participate in shear stress controlled thrombosis, but ERK2 activation is initiated predominantly via GPIb-VWF interactions