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CREM — CRH

Text-mined interactions from Literome

Liu et al., J Neuroendocrinol 2006 : The ability of ICER to inhibit CRH transcription was examined in the hypothalamic cell line, 4B, which expresses CRH ... Consistent with an inhibitory effect of CREM on CRH transcription, chromatin immunoprecipitation assays in cells transfected with ICER I revealed recruitment of CREM by the CRH promoter in conjunction with decreases in Pol II association
Aguilera et al., Stress 2007 : In addition to glucocorticoids, intracellular feedback mechanisms in the CRF neuron, involving induction of repressor forms of cAMP response element modulator (CREM) limit CRF transcriptional responses by competing with the positive regulator, phospho-CREB
Liu et al., Cell Mol Neurobiol 2009 : To determine whether endogenous ICER production represses CRH transcription, we examined the effect of CREM siRNA on forskolin stimulated ICER formation and CRH transcription in the hypothalamic cell line, 4B, and in primary cultures of hypothalamic neurons ... The role of ICER on endogenous CRH expression was studied in primary cultures of hypothalamic neurons by examining the effect of CREM siRNA on forskolin induced primary transcript ( CRH hnRNA ) using intronic real-time PCR