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MAP2K1 — TNF

Text-mined interactions from Literome

Manna et al., Biochem Pharmacol 1999 : Beta-lapachone also abolished TNF induced activation of AP-1, c-Jun N-terminal kinase, and mitogen activated protein kinase kinase ( MAPKK or MEK )
Manna et al., Oncogene 1999 : gamma-GCS also abolished the activation of AP-1 induced by TNF and inhibited TNF induced activation of JNK and mitogen activated protein kinase kinase
Manna et al., J Biol Chem 2000 : hCG abrogated the TNF induced activation of mitogen activated protein kinase kinase and c-Jun N-terminal kinase required for NF-kappaB and AP-1, respectively
Manna et al., J Immunol 2000 : Vesnarinone also blocked NF-kappa B activation induced by several other inflammatory agents, inhibited the TNF induced activation of transcription factor AP-1, and suppressed the TNF induced activation of c-Jun N-terminal kinase and mitogen activated protein kinase kinase
Manna et al., J Immunol 2000 : Resveratrol also inhibited the TNF induced activation of mitogen activated protein kinase kinase and c-Jun N-terminal kinase and abrogated TNF induced cytotoxicity and caspase activation
Wang et al., Biochem Biophys Res Commun 2001 (Brain Ischemia...) : Differential regulation of IL-1beta and TNF-alpha RNA expression by MEK1 inhibitor after focal cerebral ischemia in mice
Oshima et al., Am J Physiol Cell Physiol 2001 (Inflammatory Bowel Diseases...) : We found that MEK-1/2 is activated by TNF-alpha within minutes and is dependent on TK and p42/44 MAPKs
Séguin et al., J Cell Physiol 2003 (Arthritis...) : In both prechondrocytes and articular chondrocytes, TNFalpha induced concentration dependent activation of MEK1/2 and NF-kappaB, but not p38 or JNK
Cha et al., J Pharmacol Exp Ther 2006 : The Syk inhibitor also decreased TNFalpha induced mitogen activated protein kinase kinase ( MKK ) 4 phosphorylation but not MKK3 and MKK6 phosphorylation, which is consistent with its selective sparing of p38
Lewthwaite et al., Int Immunopharmacol 2007 (Inflammation) : Selective inhibitors of p38 ( mapk ) ( SB203580 ) or of MEK1/2 , the direct upstream activator of ERK1/2 ( PD98059 ), reduced the synthesis of IL-1beta, TNFalpha , IL-6 and IL-8 induced by either the chaperonins or LPS
Rousseau et al., J Cell Sci 2008 (MAP Kinase Signaling System) : We show that LPS stimulates the appearance of pre-TNFalpha at the cell surface and that this is prevented by inhibition of MAPK kinases 1 and 2 (MKK1/2) or in TPL2-deficient macrophages
Lee et al., J Cell Physiol 2011 : Here, we report that TNF-a induced cPLA(2) protein and mRNA expression, PGE ( 2 ) production, and phosphorylation of p42/p44 MAPK, p38 MAPK, and JNK1/2, which were attenuated by pretreatment with a ROS scavenger [ N-acetyl-L-cysteine, ( NAC ) ] and the inhibitors of NADPH oxidase [ apocynin (APO) and diphenyleneiodonium chloride ( DPI ) ], MEK1/2 ( U0126 ), p38 MAPK ( SB202190 ), and JNK1/2 ( SP600125 ) or transfection with siRNA of Nox2, p47(phox), MEK1, p42, p38, or JNK2
Manna et al., J Biol Chem 1998 : In addition, Mn-SOD blocked the TNF mediated activation of activated protein-1, stress activated c-Jun protein kinase, and mitogen activated protein kinase kinase