◀ Back to AKT2
AKT2 — TCL1A
Pathways - manually collected, often from reviews:
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Bind Interaction:
TCL1A
—
AKT2
Laine et al., J Biol Chem 2002*
-
IRef Bind_translation Interaction:
TCL1A
—
AKT2
(coimmunoprecipitation)
Laine et al., J Biol Chem 2002*
-
IRef Biogrid Interaction:
TCL1A
—
AKT2
(physical association, affinity chromatography technology)
Laine et al., J Biol Chem 2002*
-
IRef Biogrid Interaction:
TCL1A
—
AKT2
(direct interaction, two hybrid)
Laine et al., Mol Cell 2000*
-
IRef Biogrid Interaction:
TCL1A
—
AKT2
(physical association, affinity chromatography technology)
Laine et al., Mol Cell 2000*
-
MIPS CORUM TCL1(trimer)-AKT2 complex:
TCL1(trimer)-AKT2 complex complex (AKT2-TCL1A)
Laine et al., Mol Cell 2000*
-
IRef Corum Interaction:
TCL1A
—
AKT2
(association, coimmunoprecipitation)
Laine et al., Mol Cell 2000*
-
IRef Corum Interaction:
TCL1A
—
AKT2
(association, two hybrid)
Laine et al., Mol Cell 2000*
-
IRef Hprd Interaction:
TCL1A
—
AKT2
(in vivo)
Laine et al., Mol Cell 2000*, Laine et al., J Biol Chem 2002*
-
IRef Hprd Interaction:
TCL1A
—
AKT2
(in vitro)
Laine et al., Mol Cell 2000*, Laine et al., J Biol Chem 2002*
-
IRef Ophid Interaction:
TCL1A
—
AKT2
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
Text-mined interactions from Literome
Pekarsky et al., Proc Natl Acad Sci U S A 2000
:
Tcl1 enhances
Akt kinase activity and mediates its nuclear translocation
Künstle et al., Mol Cell Biol 2002
:
In vitro kinase assays and overexpression experiments in mammalian cells demonstrated that both TCL1-Akt interaction and oligomerization of TCL1 were required for
TCL1 induced
Akt activation and substrate phosphorylation ... The results demonstrate the structural basis of
TCL1 induced activation of
Akt , which causes human T-PLL
Feng et al., Am J Physiol Gastrointest Liver Physiol 2010
(Atrophy) :
We used a novel
Akt activating peptide,
TCL1 ( a head-to-tail dimer of the Akt binding domain of T-cell lymphoma-1 ), or an inactive mutant sequence TCL1G conjugated to a transactivator of transcription peptide sequence to promote intracellular uptake
Popal et al., Leukemia & lymphoma 2010
(Leukemia, Lymphocytic, Chronic, B-Cell...) :
We discuss inhibitory strategies that are based on
TCL1A 's
activation of the growth modulating kinase
AKT and on influences that regulate TCL1A expression
Miyazaki et al., PloS one 2013
:
We found that
Tcl1 expression levels correlated positively with the proliferation rate and negatively with the apoptosis of ES cells, but did not
affect Akt phosphorylation