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AKT2 — GNA12

Text-mined interactions from Literome

Kumar et al., Mol Cell Biol 2006 (Cell Transformation, Neoplastic) : Since AKT promotes cell growth by blocking the transcription of antiproliferative genes through the inhibitory phosphorylation of forkhead transcription factors, our results describe for the first time a PDGFRalpha dependent signaling pathway involving PI3K-AKT-FKHRL1 , regulated by Galpha12QL in promoting cell growth
Wu et al., FEBS J 2006 : Finally, overexpression of the dominant negative mutant of RhoA blocked G alpha12QL- and G alpha13QL mediated inhibition, suggesting that activated G alpha12 and G alpha13 inhibit Akt signaling via RhoA ... Collectively, this study demonstrated the inhibitory effect of activated G alpha11, G alpha14, G alpha16, G alpha12 and G alpha13 on pro-survival Akt signaling
Chen et al., J Nat Med 2012 (Brain Neoplasms...) : The pro-apoptotic effect of GNA on U251 cells was shown to be mediated through inactivation of the Akt pathway, because GNA efficiently suppressed the expression level of EGFR and reduced the phosphorylation of Akt ( T308 ) and GSK3ß ( S9 )