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IFNG — IL13RA2
Text-mined interactions from Literome
Daines et al., J Biol Chem 2002
:
Up-regulation of
IL-13Ralpha2 surface expression in
response to
IFN-gamma was rapid, did not require protein synthesis, and resulted in diminished IL-13 signaling
Zheng et al., J Allergy Clin Immunol 2003
:
These effects were not specific for IL-13, because transgenic IL-4, IL-10, and
IFN-gamma also
stimulated IL-13Ralpha2 mRNA accumulation while stimulating-not altering and inhibiting-IL-13Ralpha1 mRNA accumulation, respectively
Wongpiyabovorn et al., J Dermatol Sci 2003
(Dermatitis, Atopic...) :
In contrast,
IL-13Ralpha2 mRNA expression was
up-regulated by
IFN-gamma plus IL-4
Pierce et al., Am J Physiol Lung Cell Mol Physiol 2006
(Metaplasia) :
Collectively, these studies suggest that, during prolonged exposure to allergen, Bim plays no role in the resolution of GCM, but increased
IFNgamma levels in bim ( -/- ) mice may be
responsible for reduced expression of
IL-13Ralpha2 and enhanced GCM despite similar levels of IL-13 in bim ( +/+ ) and bim ( -/- ) mice