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RHOA — STAT5A

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: STAT5A → RHOA (increases, RHOA Activity, STAT5A Activity) Benitah et al., Mol Biol Cell 2003*
  Evidence: Here, we provide evidence that Rho GTPases modulate Stat5a, a transcription factor of the family of signal transducers and activators of transcription. RhoA triggers tyrosine phosphorylation (Y696) of Stat5a via a JAK2-dependent mechanism and promotes DNA-binding activity of Stat5a.

Text-mined interactions from Literome

Benitah et al., Mol Biol Cell 2003 : RhoA triggers tyrosine phosphorylation ( Y696 ) of Stat5a via a JAK2 dependent mechanism and promotes DNA binding activity of Stat5a ... Simultaneously, RhoA reduces serine phosphorylation of Stat5a at both serine residues S726 and S780, resulting in a further increase of activity as defined by mutagenesis experiments ... Thus, RhoA regulates Stat5a via tyrosine phosphorylation and via a yet to be determined novel down modulating pathway that involves serine dephosphorylation
Du et al., J Cell Physiol 2012 : Enforced activation of RhoA in MECs cultured on BM suppresses prolactin receptor levels, and prevents prolactin induced Stat5 tyrosine phosphorylation and ß-casein expression